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在甲状腺下降犬中胃肠道征兆的回顾性评估
Eleonora Gori1, Paola Gianella2, Ilaria Lippi1
1Veterinary Teaching Hospital "Mario Modenato", Department of Veterinary Sciences, University of Pisa, Via Livornese Lato Monte, 56122 Pisa, PI, Italy.
Animals : an open access journal from MDPI
|August 26, 2023
概括
甲状腺功能下降的狗表现出更高的胃肠道症状,特别是便秘和腹. 甲状腺替代疗法显著改善了这些症状,支持了犬类甲状腺功能低下症和胃肠道问题之间的联系.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
背景情况:
- 胃肠道 (GI) 症状在甲状腺功能低下的狗中很少被记录.
- 甲状腺功能低下症是狗常见的内分泌疾病,可以表现为各种临床症状.
- 了解甲状腺功能低下症和胃肠道疾病之间的关系对于准确的诊断和治疗至关重要.
研究的目的:
- 为了确定同时发生的GI症状的发病率和特征,在甲状腺功能下降的狗.
- 描述临床病理学和肝肠道超声波在甲状腺功能低下的狗的发现.
- 评估甲状腺替代疗法 (THRT) 对低甲状腺犬的胃肠道症状的影响.
主要方法:
- 两家兽医医院的医疗记录的回顾性审查.
- 纳入标准:患有甲状腺功能低下症的临床和临床病理症状的狗,不包括影响甲状腺轴的急性疾病或治疗.
- 通过甲状腺激素水平 (fT4,TT4,TSH) 和TSH刺激测试确认甲状腺功能低下症. 狗被分为甲状腺功能低下 (hypo-T) 和甲状腺功能良好组. 记录了胃肠道症状,临床病理学数据和超声检查结果. 在THRT后评估了胃肠道征兆的改善.
主要成果:
- 甲状腺功能下降的狗表现出显著更高的GI症状 (44%) 与euthyroid狗相比 (24%),便秘和腹是最常见的 (分别p=0.03和p=0.001).
- 甲状腺功能低下犬的胆囊变化的患病率高 (80%) 比甲状腺功能良好的狗 (52%) (p=0.04).
- 在甲状腺替代疗法后,低甲状腺犬的胃肠道症状显著改善 (p < 0.0001).
结论:
- 甲状腺功能低下症与狗中胃肠道症状的患病率增加有关.
- 胆囊变化可能在甲状腺功能低下的狗中更常见.
- 甲状腺激素补充后胃肠道症状的改善支持甲状腺功能低下症和这些临床表现之间存在因果关系.
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