在自身免疫性心肌炎中调节TLR4/NFκB通路
Livia Interdonato1, Daniela Impellizzeri1, Ramona D'Amico1
1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy.
Antioxidants (Basel, Switzerland)
|August 26, 2023
概括
绿白色通过减少炎症和氧化应激,有效治疗自身免疫性心肌炎. 这种天然化合物调节关键的分子通路,为心脏炎症提供了有前途的治疗方法.
科学领域:
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 心肌炎是一种炎症和氧化性疾病,导致免疫细胞透和器官功能障碍.
- 目前治疗心肌炎的方法往往有局限性,需要探索新的治疗药物.
研究的目的:
- 在自身免疫性心肌炎 (EAM) 的实验模型中研究Coriolus versicolor的治疗潜力.
- 阐明Coriolus versicolor抗炎和心脏保护作用背后的分子机制.
主要方法:
- 在使用猪心脏肌肉酶的动物中诱导了实验性自身免疫心肌炎.
- Coriolus versicolor (200 mg/Kg) 被口服使用了21天.
- 评估了分子通路,细胞因子水平,氧化应激标志物,抗氧化酶活动和组织学变化.
主要成果:
- 花粉 administration 减少了TLR4/NF-κB通路激活和促炎细胞因子 (INF-γ,TNF-α,IL-6,IL-17,IL-2),同时恢复了抗炎IL-10.
- 治疗降低了脂质过氧化和酸盐水平,增强了抗氧化酶活性 (SOD,CAT),并增加了GSH水平.
- 组织学损伤,免疫细胞透 (CD4 +,CD68 +) 和细胞亡显著减少.
结论:
- 绿呈现出显著的抗炎,抗氧化和抗丧作用在自身免疫性心肌炎.
- 该化合物调节TLR4/NF-κB信号通路,突出其治疗心肌炎的治疗潜力.
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