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韩国红人参减弱了皮肤角质细胞的颗粒物引起的衰老

Kyoung Ah Kang^1,2, Mei Jing Piao^1,2, Pincha Devage Sameera Madushan Fernando¹

¹Department of Biochemistry, College of Medicine, Jeju National University, Jeju 63243, Republic of Korea.

Antioxidants (Basel, Switzerland)

|August 26, 2023

概括

韩国红人参 (KRG) 防止皮肤细胞因细颗粒物 (PM2.5) 引起的衰老. KRG通过表观遗传调节p16INK4A基因来起作用,保护皮肤角质细胞免受PM2.5诱导的衰老.

科学领域:

皮肤病学皮肤病学
细胞生物学细胞生物学
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

皮肤受到细颗粒物 (PM2.5) 暴露的直接影响.
PM2.5诱导皮肤角质细胞中的细胞衰老,其特征是形态变化和增加p16INK4A表达.

研究的目的:

研究韩国红人参 (KRG) 对皮肤角质细胞中PM2.5诱导的衰老的保护作用.
阐明KRG的保护作用背后的表观遗传机制.

主要方法:

使用了人类角质细胞细胞系和正常的人类表皮角质细胞.
评估了细胞衰老标志物,p16INK4A表达和DNA / 基因素甲基化模式.
研究了表观遗传调节者的表达和活性,包括TET酶,DNA甲基转移酶,MLL1,HAT1,EZH2和HDAC1.

主要成果:

PM2.5诱导的衰老标志物和p16INK4A在角质细胞中的表达.
KRG抑制了PM2.5诱导的衰老和p16INK4A的表达.
通过调节TET,DNMT,MLL1,HAT1,EZH2和HDAC1的表达和活性,KRG调节了p16促进子的表观遗传修饰.
韩国政府降低了TET1,MLL1和HAT1与p16促进者的结合.

结论:

KRG显示了对PM2.5诱导的皮肤角质细胞衰老的保护作用.
KRG通过对p16INK4A基因的表观遗传调节来发挥其保护功能.

关键词:

韩国红人参是韩国的红人参.表观遗传改变表观遗传改变微细颗粒物质的细颗粒物质的细颗粒物质的细颗粒物质.皮肤细胞衰老皮肤细胞衰老

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