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红醇丰富的Magnolia officinalis树皮提取物减轻了创伤诱导的神经病痛

Vittoria Borgonetti¹, Nicoletta Galeotti¹

¹Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology, University of Florence, Viale G. Pieraccini 6, 50139 Florence, Italy.

Antioxidants (Basel, Switzerland)

|August 26, 2023

概括

在神经病痛模型中,Magnolia officinalis提取物 (MOE) 和Honokiol (HNK) 显示了缓解疼痛的效果. 这些天然化合物减少神经炎症和氧化应激,为管理这种困难的疼痛状况提供了潜力.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
自然产品化学自然产品化学

背景情况:

神经病痛 (NP) 影响8%的人口,治疗选择有限.
氧化应激和神经炎症是慢性NP的关键因素.
天然抗氧化剂对NP管理有很大的前景.

研究的目的:

在神经病痛模型中研究一种富含荣基醇 (HNK) 的Magnolia officinalis提取物 (MOE) 的疗效.
探索MOE对神经炎症和氧化应激的影响背后的分子机制.
评估HNK对炎症反应的直接影响.

主要方法:

在NP.中利用了节省神经损伤 (SNI) 鼠标模型.
口服的MOE (30 mg/kg) 和评估的抗艾洛丁效应和运动运动活性.
对炎症标志物 (p-p38,p-JNK1,iNOS,p-p65,IL-1ß,IL-10,MBP,Nrf2) 和Notch通路组件 (Jagged1,NEXT) 的脊髓组织进行了分析.
研究了HNK对LPS刺激的BV2微质细胞的影响.

主要成果:

在SNI小鼠中,MOE表现出显著的抗氨酸效应,而不会导致发动机功能障碍.
MOE降低了脊髓中神经炎症和氧化应激的关键标志物.
MOE和HNK调节了Notch信号通路,并减少了促炎性细胞因子的产生.
影响部分由CB1受体相互作用介导.

结论:

在神经病痛疼痛模型中,MOE和HNK表现出显著的止痛特性.
这些化合物通过调节氧化应激,神经炎症和Notch信号通路来发挥作用.
MOE和HNK代表了治疗神经病痛的有希望的自然疗法候选者.

关键词:

马格诺利亚官员植物 (Magnolia officinalis) 是一个植物.抗氧化剂是一种抗氧化剂.大麻素受体的受体是什么在这里,我们是Honokiol.神经炎症是一种神经炎症.神经病变性疼痛是一种神经性疼痛.

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