相关实验视频

Updated: Jul 18, 2025

Quantification of Hypopigmentation Activity In Vitro

Quantification of Hypopigmentation Activity In Vitro

Published on: March 6, 2019

鲁塔格雷奥伦斯:增强黑色素效应,保护黑色素细胞免受氧化损害

Pazilaiti Ainiwaer^1,2, Zuopeng Li¹, Deng Zang¹

¹State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Key Laboratory of Plants Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, South Beijing Road 40-1, Urumqi 830011, China.

Antioxidants (Basel, Switzerland)

|August 26, 2023

概括

来自Ruta graveolens的一种新类化合物促进了黑色素的产生,并保护皮肤细胞免受损伤. 这种化合物可能通过减少内分泌网膜应激和炎症来为白风提供一种新的治疗方法.

科学领域:

皮肤病学皮肤病学
药理学药理学是指药理学的学科.
自然产品化学化学

背景情况:

Vitiligo 是一种由黑色素细胞损失引起的获得性脱色障碍.
目前的研究旨在促进黑色素合成,并保护黑色素细胞免受损伤.
鲁塔 (Ruta graveolens L.) 是一种传统上用于治疗各种疾病的药用草本,包括白风.

研究的目的:

从Ruta graveolens提取物中分离和表征类化合物.
评估这些化合物在促进黑色素生成和保护黑色素细胞方面的潜力.
为了研究在白风中治疗应用的作用机制.

主要方法:

提取和净化16种类化合物从Ruta graveolens化提取物.
对黑色素细胞上分离的化合物的生物活性分析.
对氧化损伤,内质网膜 (ER) 应激和炎症标志物的化合物作用的评估.

主要成果:

化合物13,一种来自Ruta graveolens的化物,被确定.
化合物13促进了黑色素细胞中的黑色素的产生.
它通过降低ER应激和IL-6的调节,并抑制关键ER应激蛋白 (Bip, IRE1,p-IRE1,XBP-1) 来保护黑色素细胞免受4-tert-butylphenol (4-TBP) 诱导的氧化损伤.

结论:

来自Ruta graveolens的化合物13增加了黑色素的产生,并减少了黑色素细胞中的ER压力.
这种化合物通过抗氧化和抗炎作用显示出改善白风恶化的潜力.
鲁塔格雷沃伦斯提取物对白风具有治疗潜力,值得进一步研究.

关键词:

压力ERER压力ERER压力路塔格雷弗勒奥伦斯 (Ruta graveolens) 是一个古老的品种.化学成分化学成分化学成分黑色素的产生是黑色素的产生.在白风中,白风.

更多相关视频

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

Methods to Inhibit Bacterial Pyomelanin Production and Determine the Corresponding Increase in Sensitivity to Oxidative Stress

Methods to Inhibit Bacterial Pyomelanin Production and Determine the Corresponding Increase in Sensitivity to Oxidative Stress

Published on: August 31, 2015

相关概念视频

Pigmentation

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...

Changes in Skin Color: Clinical Perspectives

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...