周周血管脂肪组织氧化应激在肥胖中
Andy W C Man1, Yawen Zhou1, Ning Xia1
1Department of Pharmacology, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.
Antioxidants (Basel, Switzerland)
|August 26, 2023
概括
肥胖的周周血管脂肪组织 (PVAT) 功能障碍会导致氧化应激,影响血管. 在PVAT中恢复氧化还原平衡为与肥胖有关的心血管疾病提供了潜在的治疗策略.
科学领域:
- 心血管生物学 心血管生物学
- 代谢健康 代谢健康
- 脂肪组织研究研究
背景情况:
- 周血管脂肪组织 (PVAT) 在维持血管平衡和保护心血管和代谢疾病方面发挥着至关重要的作用.
- 健康的PVAT通过阿迪波金和激素调节血管度,有反应性氧物种 (ROS) 作为信号分子.
- 在PVAT中ROS生产和抗氧化防御之间的不平衡导致氧化应激,这是心血管并发症的关键因素.
研究的目的:
- 审查有关周血管脂肪组织 (PVAT) 中的活性氧物种 (ROS) 和抗氧化防御的当前发现.
- 探索PVAT氧化应激在肥胖引起的心血管疾病的病理生理学的作用.
- 讨论针对PVAT氧化应激的潜在药理干预措施.
主要方法:
- 文献综述总结了最近关于PVAT,ROS和氧化应激的研究.
- 分析涉及ROS在血管调节中的信号通路.
- 在PVAT中检查抗氧化剂防御系统.
主要成果:
- 肥胖导致功能障碍PVAT和氧化应激增加,有助于有害的血管效应.
- 在PVAT中降氧失衡被确定为肥胖相关心血管病理学的重要机制.
- 功能障碍的PVAT会分泌促进血管功能障碍的因素.
结论:
- 氧化压力是肥胖引起的心血管疾病的一个关键因素.
- 准PVAT氧化还原平衡为管理与肥胖有关的心血管并发症提供了一个有希望的治疗途径.
- 对PVAT在代谢和心血管健康中的作用进行进一步的研究是有必要的.
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