多种OMICS方法揭示了地中海饮食中精油对心脏代谢障碍的益生菌和潜在抗氧化作用,使用人性化的Gnotobiotic小鼠
María José Sánchez-Quintero1,2,3, Josué Delgado4,5, Laura Martín Chaves1,2,6
1Biomedical Research Institute of Malaga and Nanomedicine Platform (IBIMA Plataforma BIONAND), 29590 Málaga, Spain.
Antioxidants (Basel, Switzerland)
|August 26, 2023
概括
泰米花和香的精油作为益生菌,改善肠道健康,减少心脏病和2型糖尿病的标志物. 这些天然化合物在治疗慢性疾病方面表现有前途.
科学领域:
- 营养保健品和益生菌.
- 心脏代谢障碍研究研究
- 多omics分析分析多omics分析
背景情况:
- 地中海饮食草药提供营养药和益生菌的好处.
- 严重的心脏代谢障碍,包括冠状动脉疾病 (CAD) 和2型糖尿病 (T2DM),需要新的干预措施.
- 肠道微生物群失调与心脏代谢性疾病有关.
研究的目的:
- 为了研究西红 (Thymus vulgaris) 和菜 (Origanum vulgare) 精油的益生菌和抗氧化作用.
- 为了评估这些精油对肠道微生物群和宿主生理学的影响,在gnotobiotic小鼠模型中.
- 通过多omics方法探索对心脏功能和相关途径的影响.
主要方法:
- 用人类CAD/T2DM微生物群殖民的Gnotobiotic小鼠模型.
- 多omics分析 (代谢学,蛋白质学).
- 评估肠道微生物组成,短链脂肪酸,血生物标志物和心脏组织蛋白质组.
主要成果:
- 精油增加了乳酸菌的丰富性和短链脂肪酸.
- 观察到三甲基胺N-氧化物和血蛋白氧化的水平降低.
- 心脏组织分析显示了线粒体功能,氧化应激和收缩通路的丰富.
结论:
- 红枣和香精油表现出显著的益生菌和抗氧化剂特性.
- 这些影响积极影响肠道微生物群,代谢标志物和心脏功能.
- 来自地中海草药的精油是治疗慢性疾病 (如CAD和T2DM) 的有希望的营养药.
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