选择性干牛治疗对乳腺健康和牛奶微生物群的影响
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Updated: Jul 18, 2025

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Bovine Mammary Gland Biopsy Techniques
Published on: December 23, 2018
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Laura Filippone Pavesi1, Claudia Pollera1, Giulia Sala2
1Department of Veterinary Medicine and Animal Science, University of Milan, Via dell'Università 6, 26900 Lodi, Italy.
Antibiotics (Basel, Switzerland)
|August 26, 2023
概括
选择性干牛疗法 (SDCT) 对乳牛有效. 这种方法,仅将抗生素集中在受感染的动物身上,与干牛治疗 (BDCT) 相比,在分娩时没有增加新的乳内感染 (IMI) 或体细胞计数 (SCC) 的风险.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 乳制品科学 乳制品科学
- 抗微生物药物管理委员会
背景情况:
- 由于立法和消费者需求,奶牛农场面临越来越大的压力,需要减少抗微生物药物的使用.
- 传统的干牛治疗 (BDCT) 给所有的奶牛注射抗菌药物,无论感染状态如何.
- 选择性干牛疗法 (SDCT) 提供了一个潜在的替代方案,只针对受感染的动物.
研究的目的:
- 评估选择性干牛疗法 (SDCT) 与健康奶牛的全干牛疗法 (BDCT) 相比的疗效.
- 评估SDCT对体细胞计数 (SCC),乳内感染 (IMI) 和牛奶微生物群的影响.
- 确定SDCT是否可以在不损害产卵时乳腺健康的情况下实施.
主要方法:
- 牛奶样本从霍尔斯坦弗里西亚牛在干燥前 (T0) 和分娩后10天 (T1) 收集.
- 牛被随机分配给接受单独的内部乳头密封剂 (ITS) 或乳内抗生素治疗加上内部乳头密封剂 (A+ITS).
- 分析了体细胞计数 (SCC),乳内感染 (IMI) 和牛奶微生物群多样性 (α和β).
主要成果:
- 在TSI和A+ITS组之间没有观察到SCC,牛奶产量或T1.1的α多样性方面的显著差异.
- 在A+ITS组 (p < 0.033) 中,在T1观察到乳膜内感染 (IMI) 的统计学显著下降.
- 在T0和T1之间发现了牛奶微生物群的β多样性的显著差异 (p = 0.009).
结论:
- 选择性干牛疗法 (SDCT) 是健康奶牛的可行策略,在产卵时没有增加新的IMI或升高的SCC风险.
- 在SDCT中的A+ITS方法表明IMI的减少,这表明有针对性的抗生素使用可能是有效的.
- 这项研究支持通过在精心挑选的群体中实施SDCT对乳制品农场进行抗菌管理的潜力.
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