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两种新型抗微生物化合物的体外活性在MDR耐药临床分离物上

Mariam Rima¹, Niels Pfennigwerth², Martina Cremanns²

¹Team "Resist", UMR1184 "Immunology of Viral, Auto-Immune, Hematological and Bacterial Diseases (IMVA-HB)", INSERM, Faculty of Medicine, Université Paris-Saclay, CEA, LabEx LERMIT, 94270 Le Kremlin-Bicêtre, France.

Antibiotics (Basel, Switzerland)

|August 26, 2023

概括

新型抗生素cystobactamids和chelocardins对抗多种耐药性格拉姆阴性和格拉姆阳性细菌表现出强烈的活性. 这些有前途的药物在没有对现有抗生素的交叉耐药性的情况下表现出有效性,为抗击具有挑战性的感染提供了希望.

科学领域:

微生物学微生物学
药理学药理学是指药理学的学科.
传染性疾病传染性疾病

背景情况:

抗生素耐药性是一个关键的全球健康威胁,需要开发新的抗菌剂.
新型抗生素类别,包括囊杆菌胺和切洛卡丁,正在研究它们对抗耐药细菌菌株的潜力.

研究的目的:

对临床相关细菌的多样化小组进行体外评价,评估囊泡胺和胆卡丁的活性谱.
确定这些新型药物的有效性对抗多药耐药 (MDR) 和极度耐药 (XDR) 隔离物.

主要方法:

使用微稀释试验来确定最小抑制度 (MICs),MIC50s和MIC90s.
测试了一组由297个具有不同抗生素敏感性概况的グラム阴性和グラム阳性细菌分离体组成的小组.

主要成果:

赛斯托巴克塔米德对大多数肠杆菌有强烈的活性,对Pseudomonas aeruginosa和Acinetobacter baumannii有一些活性.
切洛卡丁抑制了Enterobacterales和Stenotrophomonas maltophilia,修改后的CDCHD显示了更强的疗效.
这两种抗生素类别都在体外表现出对格拉姆阳性细菌的活性,并且没有与卡巴,诺基诺或胆固醇素的交叉耐药性.

结论:

赛斯托巴克塔米德CN-DM-861和切洛卡丁CDCHD在体外对MDR和XDR细菌具有显著的抗生素活性.
这些新型药物代表了解决耐药病原体引起的难以治疗的细菌感染的有希望的候选人.

关键词:

在MDR中使用MDR.抗微生物药物是一种抗菌药物.产生碳酶的肠杆菌 CPE.在体外 (in vitro) 敏感性测试.

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