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Antibiotic Dereplication Using the Antibiotic Resistance Platform
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为了下一代抗微生物治疗药物,回归自然
Craig R MacNair1, Caressa N Tsai2, Steven T Rutherford1
1Department of Infectious Diseases, Genentech Inc., South San Francisco, CA 94080, USA.
Antibiotics (Basel, Switzerland)
|August 26, 2023
概括
大自然提供了新的抗生素解决方案,以对抗不断增长的细菌耐药性. 新技术释放了微生物潜力,以发现天然产品抗生素和基于微生物群的疗法,确保未来的抗菌治疗.
科学领域:
- 微生物学 微生物学
- 自然产品 化学 化学
- 基因组学就是基因组学.
背景情况:
- 来自自然界的抗生素对现代医学至关重要,但细菌耐药性的增加需要新的治疗策略.
- 自然产品抗生素的历史性成功,主要来自于土壤细菌,如actinomycetes,导致重新发现挑战.
- 下一代测序和生物信息学的进步揭示了环境微生物中巨大的,尚未开发的代谢潜力.
研究的目的:
- 审查目前挖掘未开发的微生物代谢潜力的战略,以发现新型抗生素.
- 突出基于微生物群的疗法的作用,作为对抗细菌感染的替代治疗策略.
- 强调自然作为下一代抗菌疗法来源的持续重要性.
主要方法:
- 探索激活微生物中静态生物合成基因集群的策略.
- 在现场培养方法的应用,以发现新的自然产品.
- 审查基于微生物群的治疗方法,包括便微生物组移植和细菌联盟,用于治疗感染.
主要成果:
- 下一代测序和生物信息学使得以前无法获得的微生物代谢途径的挖掘成为可能.
- 沉默基因集群的激活和新的培养技术可以产生新的抗生素化合物.
- 基于微生物群的疗法通过利用各种自然抗微生物机制,在对抗感染方面表现出显著的有效性.
结论:
- 自然仍然是发现新型抗生素和开发替代疗法的重要资源.
- 通过先进技术利用未开发的微生物代谢潜力是解决抗生素耐药性的关键.
- 基于微生物群的干预措施在传染病治疗中是一个有希望的前沿,补充了传统的抗生素方法.
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