帕纳克斯金生和Symphytum officinale的美特罗尼达醇增强:P.P.的新战略 感染控制 感染控制 感染控制
Salah M Ibrahim1, Abbas S Al-Mizraqchi2, Julfikar Haider3
1Department of Periodontics, College of Dentistry, University of Baghdad, Bab-Almoadham, Baghdad P.O. Box 1417, Iraq.
Antibiotics (Basel, Switzerland)
|August 26, 2023
概括
天然化合物Symphytum officinale和Panax Ginseng显示出抑制Porphyromonas gingivalis生物膜的显著潜力. 这些植物提取物,特别是与甲尼达结合时,为治疗牙周病和减少毒性因素提供了一个有希望的途径.
科学领域:
- 微生物学 微生物学
- 牙周病学 牙周病学
- 药理学是指药理学,即药理学是指药理学.
背景情况:
- Porphyromonas gingivalis 是牙周病的关键病原体,形成增强其毒性的生物膜.
- 抗生素耐药性增加迫使人们从自然来源寻找新型抗菌剂.
研究的目的:
- 为了评估Symphytum officinale和Panax人参提取物对Porphyromonas gingivalis生物膜的疗效.
- 评估这些植物提取物的协同效应与甲基尼达结合.
- 通过Acylated Homoserine Lactones (AHLs) 调查对定数感应的影响.
主要方法:
- 双重连续稀释技术,以制备各种度的植物提取物和甲尼达.
- 生物膜抑制实验使用来自牙周炎患者的 Porphyromonas gingivalis 隔离物和标准菌株.
- 乙基化同类素乳 (AHLs) 检测试验.
- 使用GraphPad Prism进行统计分析 (p < 0.05).
主要成果:
- 与甲化 (S+F) 结合的Symphytum officinale实现了98.7%的生物膜抑制,紧随其后的是Panax Ginseng与甲化 (G+F) 的98.2%.
- 来自患者的P. gingivalis分离物表现出比标准菌株更高的敏感性.
- 植物提取物及其组合显著抑制了AHL的产生 (p < 0.05).
结论:
- 辛菲 (Symphytum officinale) 和帕纳克斯人参 (Panax Ginseng) 对P. gingivalis生物膜表现出强大的抗菌活性.
- 这些天然化合物,单独或与甲尼达结合,有效地抑制生物膜形成和定数感应.
- 这些发现表明,这些植物药物在新型牙周病治疗中具有潜力.
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