酸作为潜在的术后抗菌剂在牙周炎:一个随机的,受控的,非劣势试验
Julio Cesar Plata1,2, David Díaz-Báez3, Nathaly Andrea Delgadillo3
1Master's Program in Dental Sciences, School of Dentistry, Universidad El Bosque, Bogotá P.O. Box 110121, Colombia.
低酸 (HOCl) 有效地减少了斑块,并防止了经过牙周手术后的细菌重新定居,显示出对赫西丁 (CHX) 的非劣势性. HOCl改善了牙周的愈合,提供了一个可行的替代抗菌剂.
科学领域:
- 牙周病学 牙周病学
- 抗菌疗法是一种抗菌疗法.
- 口腔微生物学 口腔微生物学
背景情况:
- 低酸 (HOCl) 在下生物膜中表现出强大的抗微生物特性,对抗阴性细菌.
- 在预防经过牙周手术后微生物重新定居的过程中,HOCl的疗效可能与赫西丁 (CHX) 相同或更高.
研究的目的:
- 为了比较HOCl和CHX协议在减少斑块指数 (PI),牙指数 (GI),口袋深度 (PD) 和临床附着水平 (CAL) 的有效性.
- 评估HOCl与CHX对开放式片脱皮 (OFD) 后的牙周病变微生物的细菌再殖民的影响.
主要方法:
- 一项非劣势随机对照试验,涉及32名经过OFD的牙周炎患者.
- 患者在手术后21天接受HOCl (0.05%,然后0.025%) 或CHX (0.2%,然后0.12%) 的治疗.
- 临床参数和细菌再定居 (qPCR) 被评估长达90天;进行了非劣势分析.
主要成果:
- 在降低PI和可比降低关键牙周病细菌方面,HOCl证明与CHX无劣.
- 无论是HOCl还是CHX协议,都有效地减少了 * Porphyromonas gingivalis * * Tannerella forsythia * * 和 * Eubacterium nodatum * * 的重新殖民.
- 对于*Treponema denticola*和*Aggregatibacter actinomicetemcomitans*来说,HOCl与CHX没有劣势.
结论:
- HOCl促进了牙周愈合的改善,并在术后阶段有效地减少了牙周病变细菌的重新定居.
- 在牙周治疗中,HOCl是一个有前途的替代抗微生物药物,与CHX.类似.
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