抗微生物药物的物理化学特征和静脉注射的实际建议:系统性审查
Fabio Borgonovo1, Massimiliano Quici2, Antonio Gidaro2
1Department of Infectious Diseases, Luigi Sacco Hospital, ASST Fatebenefratelli-Sacco, University of Milan, 20157 Milan, Italy.
Antibiotics (Basel, Switzerland)
|August 26, 2023
概括
静脉注射抗微生物药物需要仔细考虑药物的特性,以防止并发症. 本综述提供了关于安全的IV抗菌剂使用的指导,重点关注pH值,度和囊泡剂潜力.
科学领域:
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
- 临床药房 临床药房
背景情况:
- 静脉注射 (IV) 对于抗微生物药物的有效性至关重要,但会带来诸如组织透和炎等风险.
- 优化IV抗微生物药物输送需要了解药物特定的物理化学特性.
研究的目的:
- 为安全的IV抗菌药物管理提供实际建议.
- 鉴定需要根据其特性 (pH,度,囊泡性) 采取特别预防措施的抗菌药物.
主要方法:
- 随机对照试验 (RCT) 系统综述公布至2023年3月31日.
- 搜索的数据库:PubMed,Embase,EBSCO CINAHL,Cochrane 控制的临床试验. 搜索的数据库:PubMed,Embase,EBSCO CINAHL,Cochrane 控制的临床试验.
- 分析药物特性,包括稀释剂,pH值,度,输液速率和炎发病率.
主要成果:
- 包括232个涉及82种抗微生物药物的RCT.
- 37种抗生素,7种抗病毒药物,10种抗真菌药物和3种抗原动物药物符合"预防"标准.
- 药物具有极端pH值 (<5或>9),高度 (>600mOsm/L) 或水性质需要谨慎管理.
结论:
- 了解抗微生物的物理化学特性对于患者的安全至关重要.
- 适当的血管接入装置 (VAD) 选择对于对高风险抗菌素进行外周静脉注射至关重要.
- 遵守使用指南将局部副作用降至最低,并防止错误.
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