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睡眠的计算生物力学:一个系统的映射审查
Ethan Shiu-Wang Cheng1,2, Derek Ka-Hei Lai1, Ye-Jiao Mao1
1Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong.
Bioengineering (Basel, Switzerland)
|August 26, 2023
概括
计算生物力学为睡眠障碍提供了洞察力,比如阻塞性睡眠呼吸暂停和. 本次审查对其在睡眠医学和人体工程学中的应用进行了绘制,确定了研究缺口和改善睡眠健康的未来方向.
科学领域:
- 生物医学工程 生物医学工程
- 睡眠医学 睡眠医学
- 计算科学 计算科学
背景情况:
- 生物力学研究对于理解睡眠障碍病理生理学和促进睡眠健康至关重要.
- 计算方法为分析睡眠研究中的生物力学因素提供了一个强大的in silico平台.
- 本综述系统地检查了计算生物力学在各种睡眠相关研究领域的应用.
研究的目的:
- 审查和绘制计算生物力学在睡眠医学和人体工程学的应用.
- 确定与睡眠相关的当前计算生物力学研究中的研究差距和局限性.
- 为该领域的未来研究方向提供见解.
主要方法:
- 在PubMed,Scopus和Web of Science中进行系统的文献搜索.
- 符合条件的研究的数据综合和证据映射,重点是建模考虑因素和组件.
- 将27项研究分类为睡眠人体工程学,与睡眠相关的呼吸障碍 (阻塞性睡眠呼吸暂停) 和与睡眠相关的运动障碍 (睡眠 Bruxism).
主要成果:
- 计算生物力学已被应用于研究枕头/床对睡眠人体工程学中脊柱曲率的影响.
- 关于睡眠布鲁克斯症的研究主要集中在关节压力.
- 阻塞性睡眠呼吸暂停研究利用有限元素形态测量和流体结构相互作用来分析上呼吸道崩,空气流和解剖变异.
结论:
- 计算生物力学为睡眠障碍研究提供了有价值的工具,从人体工程学到呼吸和运动障碍.
- 模型验证和外部有效性仍然是重大挑战.
- 未来的研究应该专注于患者特定的模型,更大的队列,并探索阻塞性睡眠呼吸暂停治疗的计算方法.
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