隔离式超冷却器官保护系统
Gabriel Năstase1, Florin Botea2,3, George-Andrei Beșchea1
1Department of Building Services, Faculty of Civil Engineering, Transilvania University of Brasov, 500152 Brasov, Romania.
Bioengineering (Basel, Switzerland)
|August 26, 2023
概括
这项研究介绍了一种新的器官保护系统,使用同位体 (恒定体积) 超冷. 该技术成功地使猪肝保持在超冷状态,长达48小时,没有形成冰,避免了冷保护剂.
科学领域:
- 生物医学工程 生物医学工程
- 低温生物学 低温生物学
- 器官移植 器官移植
背景情况:
- 目前的器官保存方法往往依赖于冷保护剂,这可能是有毒的.
- 在没有形成冰的零下温度下长期保存大型器官仍然是一个挑战.
研究的目的:
- 引入一种基于同位体 (恒定体积) 超冷的新型器官保护系统.
- 评估系统在没有冰核形成的情况下保持生物器官在超冷状态的能力.
- 为研究人员提供技术设计和协议.
主要方法:
- 开发一种利用同位体超冷却的器官保存系统.
- 基于同位体冷热力学和压力监测的控制系统的实施.
- 使用整个猪肝进行假实验,以评估超冷却稳定性.
主要成果:
- 在猪肝组织中持续超冷,不产生冰核,持续24小时和48小时.
- 证明了大器官无需冷保护剂保存的潜力.
- 提供了详细的技术设计和使用协议的异体超冷设备.
结论:
- 隔离体超冷却系统显示出对长期,无冷保护剂的器官保存有希望.
- 该技术提供了对保存过程的实时控制.
- 需要进一步的研究来确认通过这种方法保存的器官的移植性.
相关概念视频
Transmission-based Precautions II: Airborne and Protective Environment
Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Personal Protective Equipment
Personal protective equipment (PPE) is unique clothing or equipment worn by an employee to minimize or prevent exposure to infectious agents. PPE creates a barrier between the employee and the infectious materials. PPE must be readily available in the patient care area. PPE includes gloves, gowns and aprons, masks and respirators, goggles, face shields, shoes, and headcovers:
Refrigerators and Heat Pumps
Refrigerators or heat pumps are heat engines operating in a reverse direction. For a refrigerator, the focus is on removing heat from a specific area, whereas, for a heat pump, the focus is on dumping heat into one particular area. A refrigerator (or heat pump) absorbs heat Qc from the cold reservoir at Kelvin temperature Tc and discards heat Qh to the hot reservoir at Kelvin temperature Th, while work W is done on the engine’s working substance.
A household refrigerator removes heat from the...
A household refrigerator removes heat from the...
Radial System Protection
Radial systems employ time-delay overcurrent relays to reduce load interruptions. When a fault occurs, the nearest breaker opens first, while upstream breakers remain closed due to longer delay settings. This approach ensures minimal disruption to the rest of the system.
In a radial system with a fault downstream of the third breaker, ideally, only the third breaker will open, isolating the fault and interrupting the load connected beyond it. The second breaker has a longer delay setting,...
In a radial system with a fault downstream of the third breaker, ideally, only the third breaker will open, isolating the fault and interrupting the load connected beyond it. The second breaker has a longer delay setting,...
Zones of Protection
In power systems, the entire setup is divided into protective zones to isolate faults and protect the rest of the network. These zones include generators, transformers, buses, transmission lines, distribution lines, and motors. Each zone can be visualized as a separate room in a house, with each room protected by its own circuit breaker.
Protective zones are defined by closed dashed lines, containing one or more components. A key characteristic of these zones is the strategic placement of...
Protective zones are defined by closed dashed lines, containing one or more components. A key characteristic of these zones is the strategic placement of...
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen
Oxygen therapy is a pivotal aspect of medical care, particularly for patients with respiratory ailments. Two prominent oxygen-delivering systems include the Venturi mask and the transtracheal oxygen catheter.
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...


