关于左心室附属体内部流量场的研究和使用不同血液模型进行中风风险评估
Jun Yang1, Zitao Bai1, Chentao Song1
1School of Energy and Power Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Bioengineering (Basel, Switzerland)
|August 26, 2023
概括
患有心房动 (AF) 的患者面临来自左心房尾 (LAA) 血栓的高中风险. 计算流体动力学模型显示,双相非牛顿模型更好地预测LAA中的血栓形成风险.
科学领域:
- 心血管研究研究心血管研究
- 生物医学工程 生物医学工程
- 医疗成像医学成像
背景情况:
- 心房动 (AF) 显著增加中风风险,原因是左心房附属体 (LAA) 中的血栓形成.
- 准确识别血栓形成风险对于AF患者及时干预至关重要.
研究的目的:
- 通过计算流体动力学 (CFD) 来研究AF患者LAA中的血栓形成机制.
- 用三种不同的CFD血流模型来比较血栓形成风险预测.
主要方法:
- 从AF患者的CT扫描创建了三维 (3D) 左心室 (LA) 模型.
- 在AF和鼻节律 (SR) 条件下,使用单相和双相非牛顿血流模型进行了CFD模拟.
- 使用相对居住时间 (RRT) 和内皮细胞激活潜力 (ECAP) 度量来评估血栓形成风险.
主要成果:
- 这三种CFD模型都与预测血栓形成风险的临床指南相一致.
- 单相非牛顿模型在LAA中显示较低的血液停留时间,RRT和ECAP,表明血栓形成风险降低.
- 两相非牛顿模型在LAA中显示出更高的血液停留时间和RRT,表明血栓形成风险增加.
结论:
- CFD建模为AF中LAA血栓形成机制提供了有价值的见解.
- 血流模型的选择显著影响了血栓形成风险的预测,而双相非牛顿模型提供了可能更准确的表现.
更多相关视频
08:10Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
1.7K
04:29Author Spotlight: Advancements in Intracardiac Echocardiography for Atrial Anatomy Assessment
Published on: June 30, 2023
942
相关概念视频
Blood Flow
Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
General External Flow Characteristics
The study of external flow is essential for creating structures and objects that interact efficiently and safely with moving fluids, such as air or water. When a body is immersed in a flowing fluid, it experiences two primary forces: drag, which opposes motion along the flow direction, and lift, which acts perpendicular to the flow. The shape, size, and orientation of the object influence these forces.Streamlined and Blunt Bodies in External FlowObjects in fluid flow are classified as...
Applications of Integration to Find Blood Flow
Blood flow through a cylindrical blood vessel can be mathematically described using the principles of laminar flow, a regime in which fluid moves smoothly in parallel layers. In this model, the velocity of the blood is not uniform across the cross-section of the vessel; rather, it varies with the radial distance from the center. The maximum velocity occurs along the central axis, decreasing progressively toward the vessel walls, where it reaches zero due to viscous drag.Approximating Blood...
