白质的功能性变化与持续的知觉期间的人类疼痛敏感性有关
Hui He1, Lan Hu1, Saiying Tan1
1The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu 610054, China.
Bioengineering (Basel, Switzerland)
|August 26, 2023
概括
疼痛敏感性因个人而异,可能是由于白质 (WM) 功能网络的差异. 改变WM网络中的功能连接与焦虑相关,并可能影响疼痛调制.
科学领域:
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
- 神经成像是一种神经成像.
背景情况:
- 个人对疼痛的感知有所不同,受焦虑等因素的影响.
- 白质 (WM) 功能组织影响下降疼痛调节系统.
- 功能性磁共振成像 (fMRI) 可以揭示疼痛调节期间的WM功能组织.
研究的目的:
- 研究疼痛敏感 (PS) 和疼痛不敏感 (PIS) 个体之间的白质 (WM) 功能网络的差异.
- 探索WM功能连接 (FC),疼痛敏感性和焦虑之间的关系.
- 阐明WM功能网络在疼痛处理和调制中的作用.
主要方法:
- 根据冷压器测试,招募了26名PS和27名PIS受试者.
- 在fMRI期间,受试者在正常和寒冷条件下进行了冷瓶测试 (CBT).
- 使用K-means集群分析了WM功能网络,并评估了WM和灰质 (GM) -WM网络之间的功能连接 (FC).
主要成果:
- 在寒冷条件下,在PS组的GM-小脑和WM-上时/WM-传感器运动网络之间观察到降低FC.
- 在相同条件下,在PIS集团中没有发现FC的显著差异.
- 改变的FC与PS组的状态和特征焦虑得分正相关.
结论:
- 肌痛功能网络在疼痛处理中起着至关重要的作用.
- 在WM网络中的改变FC可能与下降疼痛调节系统有关.
- 疼痛敏感度的个体差异可能与WM功能连接和焦虑水平的变化有关.
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