四维动态计算机断层扫描用于初级甲状腺功能过高症的诊断价值,在具有低基线甲状腺激素水平的患者中
Zaid Al-Difaie1, Max H M C Scheepers1, Sanne M E Engelen2
1GROW School for Oncology and Developmental Biology, Maastricht University, 6229 ER Maastricht, The Netherlands.
Diagnostics (Basel, Switzerland)
|August 26, 2023
概括
在一次性甲状腺功能障碍症 (pHPT) 中甲状腺激素 (PTH) 水平较低,降低了四维动态计算机断层扫描 (4D-CT) 引导手术的成功率. 精心的手术规划对于这些患者的切除成功至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 手术瘤学手术瘤学
- 放射学 放射学是一门学科.
背景情况:
- 低基线副甲状腺激素 (PTH) 水平与诊断和治疗原发性副甲状腺症 (pHPT) 的挑战有关.
- 这些挑战包括多腺体疾病的发病率较高,手术前成像的准确性降低,微创性甲状腺切除术的成功率较低.
- 四维动态计算机断层扫描 (4D-CT) 是局部化副甲状腺腺瘤的关键成像方式.
研究的目的:
- 评估4D-CT在局部化pHPT中的诊断性能,与高PTH水平患者相比,在PTH水平较低的患者中.
- 评估基线PTH水平对使用4D-CT.使用图像导向甲状腺切除术成功率的影响.
主要方法:
- 对接受4D-CT扫描的pHPT患者的回顾性分析.
- 患者被分为两组:基线低PTH (<100 pg/mL) 和基线高PTH (≥100 pg/mL).
- 基于病变的敏感性和成功率的比较图像引导切除在两个组之间,与手术内PTH监测.
主要成果:
- 4D-CT在两组中都显示出基于病变的高灵敏度 (低PTH为88%,高PTH为94.7%).
- 图像引导切除的成功率在低PTH组 (71.4%) 与高PTH组 (90.6%) 相比显着较低.
结论:
- 虽然4D-CT在低PTH的pHPT患者中显示出高灵敏度的病变检测,但它与图像引导切除的成功率降低有关.
- 为了在基线PTH水平较低的患者中成功进行副甲状腺切除术,需要提高外科的谨慎性和细致的探索.
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