影响自闭症谱系障碍儿童的并发症:回顾性图表审查
Jessy Burns1, Ryan Phung2, Shayna McNeill1
1SSCY Centre, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB R3E 3G1, Canada.
Children (Basel, Switzerland)
|August 26, 2023
概括
儿童自闭症谱系障碍 (ASD) 往往伴随着医学并发症,特别是神经疾病和全球发育迟缓 (GDD). 这些并发症在早产婴儿中更为频繁,并突出了自闭症的异质性,影响了预后和服务.
科学领域:
- 儿科神经学 儿科神经学
- 发育儿科 发育儿科
- 自闭症谱系障碍研究研究
背景情况:
- 自闭症谱系障碍 (ASD) 的特点是社会沟通缺陷和受限制的行为.
- 越来越多的证据突出了自闭症表现,病因和相关疾病的显著异质性.
- 了解患有自闭症的幼儿的并发症对于准确的诊断和护理至关重要.
研究的目的:
- 确定在曼尼托巴省被诊断患有自闭症儿童的医学并发症的频率和特征.
- 为了评估有或没有医疗并发症的儿童之间的ASD表现的差异.
- 探索并发症对预后和服务分配的影响.
主要方法:
- 追溯审查超过1900个电子健康记录的0-6岁儿童被诊断患有ASD.
- 纳入标准:在曼尼托巴省唯一的公共资助的ASD转诊站点诊断ASD (2016年5月 - 2021年9月).
- 使用基平方和t测试进行统计分析,以比较具有并发症和没有并发症的群体.
主要成果:
- 在1858名患有自闭症的儿童中,有29.0%患有至少一种并发症,23.0%患有全球发育迟缓 (GDD).
- 伴随性疾病在早产儿和患有GDD的儿童中更为普遍.
- 神经相关疾病是最常见的 (37.1%);女孩表现出神经和遗传相关疾病的更高率.
结论:
- 神经疾病,GDD和早产的高发病率有助于ASD异质性,使预后和服务规划复杂化.
- 根据医疗并发症来区分初级与二级ASD可能有助于个性化护理.
- 需要进一步研究伴随性疾病对自闭症结局的具体影响.
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