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一个多品种全基因组协会研究牛白细胞端粒长度

Alexander V Igoshin¹, Nikolay S Yudin¹, Grigorii A Romashov¹

¹The Federal Research Center Institute of Cytology and Genetics, The Siberian Branch of the Russian Academy of Sciences (ICG SB RAS), 630090 Novosibirsk, Russia.

|August 26, 2023

概括

我们确定了与牛白细胞端粒长度 (LTL) 相关的遗传标记,这对长寿和健康至关重要. 这些发现可以帮助改善牛特征的标记器辅助选择.

科学领域:

基因组学就是基因组学.
动物遗传学动物遗传学
分子生物学分子生物学

背景情况:

端粒在细胞分裂过程中保护染色体末端,白细胞端粒长度 (LTL) 与牛的寿命,寿命和抗病能力相关.
牛中LTL的遗传基础与人类相比,仍未得到充分探索.

研究的目的:

通过使用全基因组再测序数据计算估计牛的LTL.
进行全基因组关联研究 (GWAS),以确定影响牛LTL的遗传变异.
探索已识别的变种在牛养殖中用于标记器辅助选择的潜力.

主要方法:

分析了来自17个品种的239头牛的全基因组复序数据.
计算方法用于LTL估计.
进行了全基因组关联研究,结合了品种群和品种效应的共同变量.

主要成果:

确定了与LTL相关的42个显著单核酸多态 (SNP).
在主要品种群体中,在七个基因 (EXOC6B, PTPRD, RPS6KC1, NSL1, AGBL1, ENSBTAG00000052188, GPC1) 中发现了八个重要的SNP.
考虑品种影响的分析确定了63个SNP,其中13个在五个基因 (EXOC6B,PTPRD,RPS6KC1,ENSBTAG00000040318,NELL1) 中,包括PTPRD,以前与牛LTL相关.

结论:

该研究确定了牛中与LTL相关的显著SNP,提供了对其遗传结构的见解.
发现PTPRD基因是一个强有力的候选者,可能与替代性端粒延长有关.
已识别的基因变异为标记器辅助选择提供了潜在的可能性,以增强牛群中与LTL相关的特征.

关键词:

这里是牛群.全基因组协会研究研究.白细胞端粒的长度是什么进行全基因组再测序.

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