临床和非临床心血管疾病相关病理在帕金森病的疾病
Bonn Lee1, Charlotte Edling1, Shiraz Ahmad1
1School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, VSM Building, Daphne Jackson Road, Guildford GU2 7YW, UK.
International journal of molecular sciences
|August 26, 2023
概括
帕金森病 (PD) 研究往往忽略了心血管非运动症状 (NMS). 本综述强调了PD患者的心脏变化和α-synucleinopathy,强调需要更好的模型来研究这些影响.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 病理学 病理学 病理学
背景情况:
- 帕金森病 (PD) 的非运动性症状 (NMS) 尚未得到充分研究,特别是心血管表现.
- 在PD中,心血管表型反映了交感自主失调,为疾病的发病提供了洞察力.
- 当前的体外和体外模型不充分回顾PD相关的NMS.
研究的目的:
- 审查有关帕金森病心血管方面的现有文献.
- 在研究心血管疾病风险,心电图,神经心脏病变和PD中的电生理学方面的研究中确定共同点和局限性.
- 强调需要在PD模型中对心脏电生理学和病理学进行综合研究.
主要方法:
- 临床和非临床发表论文的系统审查.
- 分析侧重于四个关键参数:心血管疾病风险,心电图 (ECG),心脏病发病中的神经心脏病变以及心脏电生理学研究.
- 在审查的研究中确定共同的主题和局限性.
主要成果:
- 脑电图和病理学报告表明,PD患者的神经心脏调节发生变化.
- 病理学证据表明心脏参与帕金森病中的α-synucleinopathy.
- 在体外PD模型的电生理学研究中存在一个显著的差距.
结论:
- 帕金森病患者表现出与神经心脏失调和心脏α-synucleinopathy相关的心血管变化.
- 现有研究强调了研究心血管NMS的现有PD模型的局限性.
- 未来的研究应该将心脏电生理学与病理学发现相结合,以全面了解PD病变的发生.
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