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基于NGR的放射性药物用于血管新生成像:临床前审查

György Trencsényi¹, Kata Nóra Enyedi^2,3, Gábor Mező^2,3

¹Division of Nuclear Medicine and Translational Imaging, Department of Medical Imaging, Faculty of Medicine, University of Debrecen, Nagyerdei St. 98, H-4032 Debrecen, Hungary.

International journal of molecular sciences

|August 26, 2023

概括

放射标记的阿斯巴拉金-甘氨-阿尔金因 (NGR) 可以向瘤血管上的氨基酶N (APN/CD13).用于非侵入性成像. 临床前研究探索各种放射性同位素,以实现这种有前途的癌症诊断方法.

科学领域:

在瘤学瘤学.
医疗成像医学成像
放射化学放射化学是指辐射化学.

背景情况:

血管新生对于瘤生长和转移至关重要.
氨基酶N (APN/CD13) 是瘤血管和细胞的关键标记物.
准APN/CD13为癌症成像和治疗提供了潜力.

研究的目的:

为APN/CD13成像提供放射标记NGR的临床前研究概述.
要总结各种放射性同位素在开发这些成像剂中的应用.
突出NGR基于探针的潜力,用于血管生成的分子成像.

主要方法:

关于放射性标记NGR的现有文献的综述.
对临床前小动物模型进行体内成像评估的分析.
收集不同使用的正子发射断层扫描 (PET) 和单光子发射计算断层扫描 (SPECT) 放射性同位素的数据.

主要成果:

阿斯巴拉金-甘氨酸-阿尔金因 (NGR) 可以选择性地结合APN/CD13.
放射性标记的NGR对APN/CD13表达瘤的非侵入性成像显示出希望.
各种放射性同位素如68Ga,64Cu,99mTc,177Lu,188Re和213Bi已经用于标签.

结论:

放射性标记的NGR是血管生成分子成像的宝贵工具.
临床前研究表明,在基于NGR的探针中使用各种放射性金属的可行性.
这种方法对推进癌症诊断和个性化医学具有重大前景.

关键词:

NGR (阿斯巴拉金-甘氨酸-阿尔金因) 是一种氨基胺酶N (APN/CD13) 是一种血管新生是因为血管新生.在临床前的临床前.放射性同位素是一种放射性同位素.

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