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目前的治疗方法针对NAFLD的脂质代谢

Manuela Vitulo¹, Elisa Gnodi¹, Giulia Rosini²

¹School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.

International journal of molecular sciences

|August 26, 2023

概括

非酒精性脂肪性肝病 (NAFLD) 影响10亿人,缺乏特定药物. 本综述探讨了针对脂质代谢和炎症的新兴疗法,为治疗超越减肥提供了新的治疗希望.

科学领域:

肝病学和代谢疾病
药理学和治疗学药理学和治疗学

背景情况:

非酒精性脂肪性肝病 (NAFLD) 是一种普遍的疾病,全球约有10亿人受到影响.
NAFLD包括非酒精性脂肪肝 (NAFL) 和非酒精性脂肪肝 (NASH),可能会进展为肝硬化和肝细胞癌.
它经常与代谢综合征的组成部分 (如肥胖和胰岛素抵抗) 一起发生,但有效的治疗方法仍然难以捉摸.

研究的目的:

对非酒精性脂肪性肝病 (NAFLD) 的现有和新兴治疗策略进行审查.
突出新药点和正在进行的NAFLD治疗临床试验.
为了提供超出减肥建议的治疗方法的概述.

主要方法:

对NAFLD治疗方法的综合文献综述.
专注于新的治疗方法,包括针对脂质代谢和炎症的新疗法.
检查正在进行的临床试验和具有抗炎潜力的天然化合物.

主要成果:

对于NAFLD,正在研究几个治疗途径,解决其复杂的病理生理学.
新兴策略包括针对逆胆固醇运输系统和核因子 (PPAR,FXR).
重新设计的药物 (类药物,甲状腺仿制药) 和天然化合物显示出有前途.

结论:

迫切需要专门的药物来治疗NAFLD并预防其进展.
目前正在探索多种创新的治疗策略,为减肥提供潜在的替代方案或辅助措施.
对新型药物标和化合物的持续研究可能会导致NAFLD的有效治疗方法.

关键词:

肝硬化是肝硬化的一种疾病.法恩索伊德X受体 (FXR) 是一种自然化合物自然化合物非酒精性脂肪肝疾病 (NAFLD) 是一种非酒精性脂肪肝疾病.非酒精性脂肪肝炎 (NASH) 是一种疾病.过氧体增殖器激活受体 (PPAR)

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