前列腺癌:遗传学,表观遗传学和免疫生物标志物的需要
Guzel Rafikova1, Irina Gilyazova1,2, Kadriia Enikeeva1
1Institute of Urology and Clinical Oncology, Bashkir State Medical University, 450077 Ufa, Russia.
International journal of molecular sciences
|August 26, 2023
概括
来自单细胞和巨细胞的新免疫生物标志物有望改善前列腺癌 (PCa) 诊断和预后. 这些标志物可能与PCa患者的遗传风险,激素代谢和免疫反应有关.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 前列腺癌 (PCa) 是一个重大的全球健康问题,具有重大影响.
- 目前的诊断标记物,如前列腺特异性抗原 (PSA),在灵敏度和特异性方面具有局限性,导致过度诊断和医疗保健成本增加.
- 遗传和表观遗传因素影响PCa的发展,但缺乏可靠的临床标志物.
研究的目的:
- 审查免疫生物标志物的潜力,以提高前列腺癌诊断和预后.
- 要突出最近在识别循环单细胞和瘤相关巨细胞 (TAMs) 中生物标记物的进展.
- 探索这些生物标志物如何弥合PCa.的遗传倾向,激素代谢和免疫反应之间的差距.
主要方法:
- 文献综述侧重于流行病学数据,前列腺癌的遗传和表观遗传变化.
- 对免疫生物标志物的最新研究分析,包括循环和瘤内标志物.
- 强调来自单细胞和TAMs的生物标志物.
主要成果:
- 免疫学生物标志物,特别是来自单细胞和TAMs的生物标志物,显示出改善PCa诊断和预后的潜力.
- 这些新型生物标志物可能有助于在PCa中建立遗传因素,激素代谢和免疫系统活性之间的联系.
- 目前的基因标记物尚未在临床上可靠,像PSA这样的现有标记物也有局限性.
结论:
- 开发新的免疫生物标志物对于推进前列腺癌诊断,预后和管理至关重要.
- 单细胞衍生的生物标志物和TAM衍生的生物标志物代表着一个有前途的研究途径.
- 这些生物标志物可以提供更全面的了解PCa的发展和进展.
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