纳米颗粒在医学中:癌症治疗的现状
Krešimir Pavelić1, Sandra Kraljević Pavelić2, Aleksandar Bulog3,4
1Faculty of Medicine, Juraj Dobrila University of Pula, Zagrebačka 30, 52100 Pula, Croatia.
International journal of molecular sciences
|August 26, 2023
概括
纳米技术通过开发向瘤和降低毒性纳米颗粒来提供创新的癌症治疗方法. 本综述探讨了先进的纳米粒子和纳米配方,以改善癌症治疗和临床应用.
科学领域:
- 在瘤学瘤学.
- 材料科学 材料科学 材料科学
- 纳米医学是一种纳米医学.
背景情况:
- 癌症仍然是导致死亡的主要原因,特别是在晚期,转移性阶段被诊断出来时.
- 目前对晚期癌症的治疗方法通常集中在将疾病作为慢性疾病的管理上.
- 纳米技术为增强现有癌症疗法和开发新型治疗策略提供了一个有前途的途径.
研究的目的:
- 审查最先进的纳米粒子和纳米配方用于癌症治疗.
- 讨论各种纳米粒子的作用机制和诊断潜力.
- 确定阻碍这些纳米技术临床应用的局限性.
主要方法:
- 关于纳米粒子在癌症治疗中的当前文献的综述.
- 讨论各种纳米粒子类型,包括金属,聚合物,碳基和纳米泡.
- 对纳米粒子机制的分析,如活性氧物种诱导和有针对性的传递.
主要成果:
- 纳米颗粒可以改善瘤和转移细胞的向作用,降低全身毒性.
- 不同的纳米粒子 (例如,黄金,银,量子点,碳纳米管,纳米泡) 显示出用于癌症治疗的各种机制.
- 纳米泡显示出在瘤组织中增强抗癌分子局部化的潜力.
结论:
- 纳米技术在推进癌症治疗和诊断方面具有重大潜力.
- 需要进一步的研究和开发,以克服临床翻译的挑战.
- 优化的纳米粒子配方可以导致更有效,更少的毒性癌症疗法.
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