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通过β2-上腺素受体介导的T细胞功能抑制及其对CAR-T细胞治疗的影响

Muhammad Asad Farooq1, Iqra Ajmal1, Xinhui Hui1

  • 1Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, China.

International journal of molecular sciences
|August 26, 2023
PubMed
概括

瘤微环境通过上腺素 (NA) 抑制免疫反应,激活T细胞上的β2-上腺素受体 (β2-ARs). 阻断β2-AR增强了T细胞活性,这表明它是CAR-T细胞疗法的治疗点.

关键词:
在CAR-T疗法中,免疫抑制是一种免疫抑制.免疫疗法 免疫疗法瘤微环境是一个微环境.在β2-上腺素受体.

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