影响性血清激酶 (非sFlt-1) 和酶在产前-系统性审查和元分析中
Karla Cecilia Marrufo-Gallegos1, Jose Rafael Villafán-Bernal2, Salvador Espino-Y-Sosa3,4,5
1Obstetrics and Gynecology Department, Hospital General de Mexico, Mexico City 06720, Mexico.
International journal of molecular sciences
|August 26, 2023
概括
这项研究确定了预测妊娠前 (PE) 的关键生物标志物. 血清肌酸激酶 (CK) 含量较高,而可溶性氨酸蛋白激酶受体2 (sTIE2) 和可溶性c-Met在PE妇女中较低.
科学领域:
- 生物化学 生物化学
- 生殖医学 生殖医学
- 生物标志物发现发现
背景情况:
- 早期预孕前 (PE) 预测至关重要,但在sFlt-1.0之外存在有限的生物标志物.
- 激酶和酸酶在生物过程中至关重要,可能在PE中发挥作用.
研究的目的:
- 系统地审查和分析血清激酶和酸酶水平,以确定潜在的PE生物标志物.
- 为了确定特定的激酶和酸酶血清水平是否在PE和没有PE的女性之间有所不同.
主要方法:
- 根据柯克兰和PRISMA指南进行系统审查和元分析.
- 搜索了PubMed,PROSPERO和Cochrane数据库,使用关键词:孕前,激酶,酸酶,血管蛋白,sTIE2和c-MET.
- 使用R Studio对37项研究的数据 (24,211名女性) 进行了定性和定量分析.
主要成果:
- 血清肌酸激酶 (CK) 在PE中显著更高.
- 在PE中,可溶性氨酸蛋白激酶受体2 (sTIE2) 和可溶性c-Met显著较低.
- 在AMPK,ANG-1,ANG-2,ANG-1/ANG-2比率,酸酸酶或酸酸酶方面没有发现显著差异.
结论:
- 血清CK,sTIE2和c-MET显示出作为PE预测相关生物标志物的潜力.
- 将这些生物标志物纳入当前的PE预测模型需要进一步评估.
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