牙周细菌在动脉样硬化中的作用
Xiaofei Huang1,2,3, Mengru Xie1,2,3, Xiaofeng Lu1,2,3
1Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
International journal of molecular sciences
|August 26, 2023
概括
牙周炎是一种口腔感染,增加了动脉样硬化 (AS) 的风险,这是心血管疾病的主要原因. 在牙疾病中发现的特定细菌有助于AS斑块的发展和不稳定.
科学领域:
- 心血管科学 心血管科学
- 传染性疾病 传染性疾病
- 口腔健康 口腔健康
背景情况:
- 动脉样硬化 (AS) 是心血管疾病 (CVD) 和中风的主要原因,受到炎症过程的显著影响.
- 感染被认为是导致AS发展的重要因素.
- 牙周炎是一种常见的口腔感染,在流行病学上与AS和CVD的易感性增加有关.
研究的目的:
- 审查在动脉样硬化斑块中发现的流行牙周病原体.
- 检查流行病学证据,将这些病原体与AS和相关疾病联系起来.
- 阐明牙周病原体对AS病原体的产生有所贡献的机制.
主要方法:
- 流行病学研究的文献综述.
- 在动脉样硬化病变中识别关键牙周病原体.
- 分析建议的细菌参与AS的病理机制.
主要成果:
- 常见的牙周病原体,如 * Porphyromonas gingivalis *, *Aggregatibacter actinomycetemcomitans * 和 * Fusobacterium nucleatum * 在动脉样硬化斑块中发现.
- 有证据支持这些病原体与AS相关疾病之间存在关联.
- 机制包括内皮屏障破坏,免疫激活,增强单细胞粘附和泡细胞形成.
结论:
- 牙周病原体在动脉样硬化的发展和进展中起着复杂的作用.
- 了解口腔细菌和AS之间的相互作用提供了潜在的治疗策略.
- 进一步研究牙周炎和AS之间的关系对于预防和管理至关重要.
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