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患有子宫内膜异位症的妇女中HOXA10基因表达:系统性审查

Nurunnajah Lazim¹, Marjanu Hikmah Elias^1,2, Zulazmi Sutaji^1,2

¹Advanced Reproductive Centre (ARC) HCTM UKM, Department of Obstetrics & Gynecology, Faculty of Medicine, National University of Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, Kuala Lumpur 56000, Malaysia.

International journal of molecular sciences

|August 26, 2023

概括

在患有子宫内膜异位症的女性中,homeobox A10 (HOXA10) 基因经常被降低调节,这可能会影响生育能力. 测量HOXA10基因表达可能有助于预测子宫内膜异位症和子宫内膜接受性.

科学领域:

生殖生物学生殖生物学
分子遗传学分子遗传学
妇科妇科妇科妇科

背景情况:

子宫内膜异位症的发病原因尚不清楚,对家庭盒A10 (HOXA10) 基因的作用的理解有限.
HOXA10与子宫内膜异位症有关,但其精确的机制和表达模式需要进一步阐明.

研究的目的:

在不同人群中审查和分析具有和没有子宫内膜异位症的女性的HOXA10基因表达差异.
在子宫内膜异位症的背景下,讨论HOXA10基因表达对女性生育能力的影响.

主要方法:

在Scopus,ScienceDirect,PubMed和Web of Science数据库中进行系统的文献搜索.
关键词包括HOXA10,基因表达和子宫内膜异位症.
包括10项具有公平质量评级的研究.

主要成果:

在患有子宫内膜异位症的女性中,HOXA10基因表达主要被发现是下调的.
一项研究表明HOXA10表达的下调和上调,这取决于子宫内膜病变的位置.
在不同的国家和不同的人群中,HOXA10表达水平有所不同.

结论:

HOXA10基因表达是女性健康的重要指标.
测量HOXA10表达对于预测子宫内膜异位症和评估子宫内膜接受度具有临床价值.
对HOXA10基因表达的分析有助于理解足动物在黄体阶段的发育.

关键词:

霍克斯 (HOX) 是一个假象.这就是HOXA10A.子宫内膜异位症是什么?子宫内膜异位症是什么这是子宫内膜的内分泌物.基因基因基因基因基因表达的基因表达方式

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