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OLR1 是一种泛癌预后和免疫治疗预测因子,与HNSCC中的EMT和cuproptosis相关

Lei Wu¹, Yuantong Liu¹, Weiwei Deng¹

¹State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China.

International journal of molecular sciences

|August 26, 2023

概括

在大多数癌症中,OLR1基因的表达很高,并且与预后不佳和免疫逃逸有关. OLR1 可能作为癌症免疫治疗的生物标志物,并参与上皮细胞-介质细胞过渡和cuproptosis.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
免疫学免疫学免疫学

背景情况:

代谢对于癌症的发展至关重要.
目前尚不清楚OLR1在瘤发生和瘤免疫力中的作用.
OLR1因其参与心血管和代谢疾病而闻名.

研究的目的:

用TCGA数据分析各种癌症中的OLR1表达.
研究OLR1的预后价值及其与瘤免疫和免疫治疗的相关性.
探索OLR1在表皮细胞-介质细胞过渡 (EMT),茎状性和头支状细胞癌 (HNSCC) 中的cuproptosis中的作用.

主要方法:

关于OLR1表达和预后影响的TCGA数据库的泛癌分析.
免疫透,丰富和TIDE分析以评估OLR1与瘤免疫和免疫治疗的联系.
在HNSCC中进行免疫组织化学,GSEA,相关性分析和体外实验 (scratch,Transwell,CCK8,球体形成,流细胞计,免疫阻塞).

主要成果:

在大多数癌症中,OLR1的表达很高,与不良的预后相关.
OLR1的表达与免疫抑制细胞,免疫检查点的增加以及T细胞效应者的减少有关.
在HNSCC中高的OLR1水平与晚期,不良结果,免疫逃脱和免疫治疗的益处降低相关,可能影响EMT和cuproptosis耐药性.

结论:

OLR1是一种与免疫相关的预后生物标志物,有可能作为免疫疗法疗效的预测指标.
OLR1表达与瘤免疫微环境调节有关,影响患者的预后.
OLR1可能在调节HNSCC中的EMT和cuproptosis中发挥作用,这表明了治疗点.

关键词:

在EMT中,EMT是EMT.一个OLR1一个OLR1 这就是cuproptosis.免疫疗法免疫疗法预后预后预后

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