具有抗癌活性的五环三类植物化学物质:关于机制和向交付的最新研究
Madalina Nistor1,2, Dumitrita Rugina1,2, Zorita Diaconeasa1,2
1Department of Biochemistry, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania.
International journal of molecular sciences
|August 26, 2023
概括
五环三类药物显示出抗癌潜力. 将这些化合物封装在纳米脂质载体中,特别是用于声波的微泡,可以提高它们的向传递和对瘤细胞的有效性.
科学领域:
- 植物化学 植物化学
- 纳米技术纳米技术
- 在瘤学瘤学.
背景情况:
- 五环三类 (Pentacyclic triterpenoids,简称TTs) 是一种具有已证明药理作用的植物化学物质.
- 贝图林酸 (BA) 和贝图林 (B) 是TT,主要研究其抗癌性质.
- 对于有效的药物输送来说,TT的有限溶解性带来了挑战.
研究的目的:
- 审查TTs的抗癌机制和结构-活性关系.
- 探索TT在纳米脂质输送系统中纳入时的增强疗效.
- 讨论使用TT载纳米结构进行向药物递送的新策略.
主要方法:
- 在体外和体内对TT的研究的系统性文献综述.
- 分析TTs作为自由分子与封装在脂质体或纳米脂质中的分析.
- 对脂质体-TTs和纳米脂质-TTs的超分子结合体与用于声波的微泡的研究.
主要成果:
- 在体外和体内,TTs对瘤细胞表现出显著的影响.
- 纳米脂质载体和脂质体提高了TT的传递和效率.
- 带有微气泡的TT综合体提供了一种新的方法,通过声波穿孔进行有针对性的输送.
结论:
- 有针对性的输送系统,特别是与微泡相连的纳米脂质-TTs,是提高TT疗效的有希望的策略.
- 声波检测为改善脂友性TT的药物输送提供了一个新的途径.
- 需要进一步的研究来克服挑战,并推进这些纳米技术解决方案用于癌症治疗.
相关概念视频
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
Drugs that Stabilize Microtubules
2.1K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.1K
Inhibition of Cdk Activity
4.8K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.8K
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
Drugs that Destabilize Microtubules
2.0K
Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
2.0K
Cancer Vaccines
400
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
400


