在PCOS患者中异常的HPO轴变化和自身免疫异常 DOR:回顾性分析
Xueying Geng1,2,3, Zhihong He1, Zhouzhou Bao1
1Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.
Journal of clinical medicine
|August 26, 2023
概括
多囊性卵巢综合征 (PCOS) 患者的卵巢储备减少 (DOR) 呈现出改变的下丘脑-垂体-卵巢 (HPO) 轴激素和增加的自身免疫抗体. 自身免疫因素可能会导致PCOS妇女的DOR.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 免疫学 免疫学 免疫学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 多囊性卵巢综合征 (PCOS) 可以与卵巢储备减少 (DOR) 共存.
- 了解PCOS,DOR以及相关的代谢和免疫因素之间的相互作用对于患者管理至关重要.
研究的目的:
- 为了研究具有和没有DOR的PCOS患者之间的葡萄糖脂代谢,下丘脑-垂体-卵巢 (HPO) 轴参数和自身免疫抗体的差异.
- 确定可能导致PCOS妇女DOR的潜在潜在机制.
主要方法:
- 对2307名PCOS患者的回顾性分析 (1757名单独PCOS,550名PCOS与DOR).
- 测量和比较葡萄脂代谢标记物,HPO轴激素 (FSH,LH,E2,PRL) 和自身免疫抗体 (AOAb,21-OHAb).
主要成果:
- 在PCOS患者中,DOR患病率为23.84%.
- 在PCOS与DOR和PCOS没有DOR组之间观察到HPO轴激素 (FSH,LH,E2,PRL) 的显著差异.
- 在患有DOR的PCOS患者中发现了抗卵巢抗体 (AOAb) 和抗-21-OH抗体 (21-OHAb) 的水平升高;FSH与LH,和androstenedione相关,但BMI调整后的葡萄脂代谢没有.
结论:
- 患有DOR的PCOS患者呈现出更失调的HPO轴激素配置文件和更高的自身免疫抗体水平.
- 自身免疫因素被认为是诊断为PCOS的女性DOR的潜在原因.
相关概念视频
02:07Oogenesis
63.8K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.8K
01:28Obsessive-Compulsive Disorder
162
Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
162
01:30Hormonal Control of the Ovarian Cycle
568
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
568