短视的治疗与阿特罗宾0.125%每晚一次与阿特罗宾0.125%每隔一晚相比:试点研究
Zi-Rong Chen1, Shin-Chieh Chen2,3, Tsung-Yao Wan1
1College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Journal of clinical medicine
|August 26, 2023
概括
每天晚上或每隔一晚使用的低剂量氨酸眼药在减缓儿童近视的进展方面表现出类似的有效性. 每隔一晚服用0.125%的阿特罗平可能是治疗儿科近视的可行的替代方案.
科学领域:
- 眼科医生 眼科 眼科
- 儿科医学 儿科医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 近视或近视是儿童日益严重的公共卫生问题.
- 低剂量氨酸眼滴是减缓近视进展的常见治疗方法.
- 了解最佳剂量方案对于有效的近视管理至关重要.
研究的目的:
- 为了比较每晚 (HS) 和每隔一晚 (QON) 服用0.125%的阿特罗平在治疗儿童近视的疗效.
- 评估不同阿特罗平0.125%剂量频率对轴长和折射误差进展的影响.
主要方法:
- 回顾性队列研究分析了儿科近视患者的病历.
- 有两个组:阿特罗平0.125%HS和阿特罗平0.125%QON.
- 一般估计方程 (GEE) 模型用于分析治疗效应和影响因素.
主要成果:
- 在16.9个月后,QON和HS组之间没有显著的基线差异或轴长度 (AL) 和循环球相等值 (SEq) 的变化.
- 甲氨酸0.125%的频率 (QON与HS) 与年度AL或SEq变化没有关联.
- 较高的基线年龄与AL延长的减少有关 (B = -0.020,p < 0.001).
结论:
- 在这项试点研究中,施用Atropine 0.125%的HS和QON表现出类似的治疗效果.
- 氨酸0.125%QON为儿童提供了潜在的替代方案,这些儿童在晚上服用时会出现副作用.
- 建议进行进一步的大规模研究来证实这些发现.
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