微生物群对肠-大脑轴的影响:检查复杂的相互作用和影响
Tuba Shahid Chaudhry1, Sidhartha Gautam Senapati2, Srikanth Gadam3
1Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Journal of clinical medicine
|August 26, 2023
概括
肠道和大脑双向通信,影响神经和胃肠道 (GI) 的健康. 了解这种肠-大脑轴对于管理影响这两个系统的疾病至关重要.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
背景情况:
- 中枢神经系统 (CNS) 和肠道神经系统 (ENS) 分享了一个成熟的双向通信通道.
- 肠道神经系统,通常被称为"第二大脑",在肠道功能中起着至关重要的作用,并影响整体健康.
- 现有的研究强调了神经系统疾病对肠道的影响,反之亦然,但需要进行全面的综合.
研究的目的:
- 阐明中枢神经系统-ENS轴的结构和功能.
- 探索神经系统疾病如何通过ENS影响肠道,并诱导解剖或生理变化.
- 研究神经发育,认知,肠道功能和肠道微生物组之间的关系.
主要方法:
- 综合文献综述. 这是一个全面的文献综述.
- 分析关于中枢神经系统-脑神经系统轴,神经系统疾病和胃肠功能现有研究.
- 专注于神经发育,认知,肠道微生物群及其相互联系.
主要成果:
- 压力显著影响胃肠道运动性,粘膜完整性和中枢神经系统感官感知.
- 血清素 (5-HT) 突变会影响器官发育,情绪和行为.
- 肠道微生物群的变化与神经退行性疾病有关,中枢神经系统疾病可能会影响内脏神经系统.
结论:
- 胃肠道和神经心理症状之间存在协同关系.
- 肠-大脑轴在维持整体健康方面发挥着至关重要的作用.
- 行为疗法应纳入涉及中枢神经系统和内枢神经系统的疾病管理计划.
相关概念视频
Anatomy of the Intestines
72.4K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
72.4K
Irritable Bowel Syndrome I: Introduction
313
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
313
Bacterial Flora of the Large Intestine
512
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
512
Physiology of Enteric Nervous System and Gut Health
308
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
308
Neurotransmitters
1.0K
Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
1.0K
The Blood-brain Barrier
47.5K
Overview
47.5K


