增加大脑前额前部连接预测了先天性心脏病中的执行功能不佳
Aurelia Sahel1,2, Rafael Ceschin1,2, Daryaneh Badaly3
1Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Journal of clinical medicine
|August 26, 2023
概括
年轻人的先天性心脏病 (CHD) 与大脑连接的改变有关,特别是在认知途径中. 这项研究表明,特定的连接性变化预测了心脏病患者儿童的认知和运动缺陷.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 儿童心脏病学 儿童心脏病学
背景情况:
- 患有先天性心脏病 (CHD) 的儿童和青少年面临认知障碍的风险,包括执行功能缺陷和运动延迟.
- 这些缺陷可能会对学业成绩,适应性功能和整体生活质量产生负面影响.
研究的目的:
- 为了研究患有心血管疾病和健康对照人群之间的前额前脑大脑连接的差异.
- 为了确定这些连接性改变是否可以预测患有心脏病的年轻人的认知或运动障碍.
主要方法:
- 利用多模态磁共振成像 (MRI),包括扩散张力成像,对53名心脏病患者和73名健康对照进行了多模态磁共振成像.
- 测量小脑与前额叶皮层的连接性,使用概率学曲道学.
- 通过NIH工具箱的神经心理测试评估认知和运动技能.
主要成果:
- 与对照人群相比,患有心血管疾病的个体在认知循环连接路径中呈现出较高的分数异构性 (FA).
- 两组之间没有发现电机循环连接的显著差异.
- 在特定的认知循环通道中增加的FA预测了CHD参与者的执行功能得分较低.
- 与年轻或年长个体相比,患有心脏病的青少年表现出认知循环连接的暂时增加.
结论:
- 在认知循环中改变小脑-大脑连接性与患有心脏病的年轻人的认知功能障碍有关.
- 青春期似乎对小脑电路可塑性影响心脏病中神经认知功能至关重要.
- 建议在不同儿科心血管疾病队列进行进一步验证.
更多相关视频
07:42Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients
Published on: December 16, 2022
3.0K
08:43Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
Published on: August 7, 2017
7.9K
相关概念视频
01:14Role of Cerebellum and Prefrontal Cortex in Memory
474
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
474
01:30Attention-Deficit/Hyperactivity Disorder
131
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
131
01:29Heart Failure II: Pathophysiology
15
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
15