相关实验视频

Updated: Jul 18, 2025

Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice

Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice

Published on: January 7, 2019

全身冷疗法改变了绝经后妇女的循环微RNA特征

Magdalena Wiecek¹, Justyna Kusmierczyk¹, Jadwiga Szymura²

¹Department of Physiology and Biochemistry, Faculty of Physical Education and Sport, University of Physical Education in Kraków, 31-571 Kraków, Poland.

Journal of clinical medicine

|August 26, 2023

概括

全身冷疗法 (WBC) 影响了新陈代谢综合征 (MetS) 的绝经后妇女的微RNA (miR) 表达. 白血球有效调节特定的miRs并降低禁食血糖,这表明它有可能作为对MetS和高血糖症的辅助治疗.

科学领域:

内分泌学和新陈代谢学
分子生物学分子生物学
冰冷疗法研究研究

背景情况:

代谢综合征 (MetS) 的发生率随着年龄的增长而增加,特别是在女性中.
微RNAs (miRs) 与代谢调节有关,但它们在MetS中的特定作用需要进一步阐明.
患有MetS的绝经后妇女面临着独特的代谢挑战.

研究的目的:

确定特定的微RNA (miRs),可以作为MetS.可靠的生物标志物.
评估全身冷疗法 (WBC) 对患有MetS的绝经后妇女miR表达的影响.
为了评估在WBC治疗后禁食血糖和脂质概况的变化.

主要方法:

研究包括患有MetS的绝经后妇女 (M-60),健康的绝经后妇女 (H-60) 和健康的年轻妇女 (H-20).
测量了miR表达 (miR-15a-5p,miR-21-5p,miR-23a-3p,miR-146a-5p,miR-197-3p,miR-223-3p),禁食血糖 (FBG),以及脂质的情况.
测量是在WBC之前进行的,在10次WBC会议之后,在20次WBC会议之后 (3分钟,-120°C).

主要成果:

确定了miR-23a-3p和miR-197-3p作为MetS及其风险因素的准确标志物.
miR-15a-5p和miR-23a-3p作为身体组成障碍的标记物表现得精确.
在所有组中,WBC治疗导致miR-15a-5p上调和FBG减少,在M-60后-20 WBC中效果增强.

结论:

特定的miRs (miR-23a-3p,miR-197-3p,miR-15a-5p) 可以作为MetS和相关的代谢和身体组成障碍的宝贵生物标志物.
全身冷疗法 (WBC) 在调节miR表达和改善血糖控制方面表现出有效性.
白血球可能是一个有益的辅助疗法,用于管理MetS和高血糖症,特别是在绝经后的妇女.

关键词:

代谢综合征代谢综合征调节新陈代谢调节新陈代谢微RNAs的表达方式绝经后的妇女绝经后的妇女内在的肥胖症内在的肥胖症全身冷疗法全身冷疗法

更多相关视频

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform

Published on: November 30, 2016

相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...