日本自身免疫性肝炎患者的SARS-CoV-2疫苗接种反应:倾向性得分匹配病例对照研究结果
Kei Moriya1,2, Tomoko Nakakita3, Natsuki Nakayama3
1Department of Gastroenterology, Nara Prefecture General Medical Center, Nara 630-8581, Japan.
Journal of clinical medicine
|August 26, 2023
概括
与健康人相比,日本自身免疫性肝炎 (AIH) 患者在接种疫苗后的SARS-CoV-2抗体水平较低. 广泛接种疫苗至关重要,特别是对于那些接受免疫抑制疗法的人来说.
科学领域:
- 免疫学 免疫学 免疫学
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
背景情况:
- 由于正在进行的病毒突变,COVID-19仍然是一个威胁.
- 积累医学证据对于保护脆弱人群至关重要,包括那些接受免疫抑制治疗的人群.
- 了解自身免疫性肝炎 (AIH) 患者的SARS-CoV-2疫苗接种反应至关重要.
研究的目的:
- 为了比较与健康对照对AIH的日本患者的SARS-CoV-2疫苗接种反应.
- 为了评估AIH患者接种疫苗后的抗SARS-CoV-2抗体度.
主要方法:
- 一项观察性研究涉及22名AIH患者和809名健康对照.
- 在接种疫苗之前和之后测量Elecsys抗SARS-CoV-2抗体度.
- 年龄和性别匹配分析以比较抗体反应.
主要成果:
- 与对照人群相比,AIH患者,特别是服用类固醇或阿扎西奥普林的患者,在第二次接种疫苗后表现出明显较低的抗SARS-CoV-2突起抗体度.
- 在第二剂后26周,更高比例的AIH患者具有最小的抗体反应 (≤100 BAU/mL).
- 年龄与两组抗体度有负相关性.
结论:
- 与健康个体相比,AIH患者对SARS-CoV-2疫苗接种的抗体反应减弱.
- 建议继续进行疫苗接种,特别强调免疫功能低下的患者,如AIH患者.
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