细胞外囊泡和癌症多药性耐药性:不必要的细胞间信使?
María Bucci-Muñoz1, Aldana Magalí Gola1, Juan Pablo Rigalli2
1Facultad de Ciencias Bioquímicas y Farmacéuticas (UNR), Instituto de Fisiología Experimental (CONICET), Rosario 2000, Argentina.
Life (Basel, Switzerland)
|August 26, 2023
概括
细胞外囊泡 (EVs) 通过在细胞之间运输ATP结合盒 (ABC) 载体,它们的mRNA或调节分子来调节癌症多药性耐药性 (MDR) 的传输. 本综述探讨了MDR中的EV角色,提供了治疗点.
科学领域:
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
- 分子医学是分子医学.
背景情况:
- 癌症多药耐药性 (MDR) 显著限制治疗疗效和生存率.
- 过度表达ATP结合盒 (ABC) 载体是MDR的主要驱动因素.
- 细胞外囊泡 (EVs) 是细胞间通信的关键媒介,转移分子载荷并影响受体细胞表型.
研究的目的:
- 通过EV介导的细胞间通信对ABC载体的调节进行现有科学证据的审查.
- 探索EVs在癌细胞之间MDR转移中的作用.
- 讨论针对EV介导的MDR的潜在治疗策略.
主要方法:
- 对调查癌症多药耐药性中EV介导通信的研究进行文献综述.
- 分析EV转移ABC载体,编码mRNA,调节蛋白和非编码RNA的机制.
- 通过EVs检查MDR转移和药物敏感表型转移的证据.
主要成果:
- EVs可以通过将ABC载体蛋白或它们的mRNA在耐药和药物敏感的癌细胞之间转移MDR.
- 调控蛋白和非编码RNA的EV介导转移也有助于诱导MDR.
- 通过EVs记录了药物敏感表型的转移,以及影响MDR的非瘤和瘤细胞之间的相互作用.
结论:
- 在癌症多药耐药性的细胞间转移中,EVs起着至关重要的作用.
- 了解EV介导的MDR机制可以识别新的可用药物标和治疗策略.
- 为了开发创新的治疗方法,需要进一步研究EV与癌细胞通信的尚未研究的方面.
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