在β-乳糖酶类型的Acinetobacter baumannii和抗菌素耐药性之间的关联
Kristina Černiauskienė1, Asta Dambrauskienė1, Astra Vitkauskienė1
1Department of Laboratory Medicine, Faculty of Medicine, Medical Academy, Lithuanian University of Health Science, Eivenių g. 2, LT-50161 Kaunas, Lithuania.
Medicina (Kaunas, Lithuania)
|August 26, 2023
概括
宝曼尼菌株对多种抗生素,特别是四环素的耐药性增加,与多种β-lactamases的产生有关. 这一趋势在2016-2017年和2020-2021年期间恶化.
科学领域:
- 临床微生物学 临床微生物学
- 抗微生物耐药性 抗微生物耐药性
- 传染性疾病 传染性疾病
背景情况:
- 宝曼尼菌 (Acinetobacter baumannii) 是一种具有固有的和获得的抗生素耐药性的重大医院病原体.
- 这种病原体在抗微生物药物治疗期间可以迅速发展出耐药性,使治疗结果复杂化.
- 了解耐药性模式及其演变对于有效的感染控制至关重要.
研究的目的:
- 描述Acinetobacter baumannii对beta-lactams和其他抗生素的耐药性.
- 评估耐药性表型之间的关联.
- 评估5年时间内抗生素耐药性的变化 (2016-2017年 vs. 2020-2021年).
主要方法:
- 在2016-2017年和2020-2021年期间从临床标本中分离的233种Acinetobacter baumannii菌株的分析.
- 使用ESBL加AmpC屏幕磁盘测试和美罗胺磁盘测试,检测β-乳酸酶类型的表型检测.
- 对抗生素耐药性概况的评估,包括卡巴,tigecycline,tetracyclines和aminoglycosides.
主要成果:
- 所有菌株表现出对西普洛素的耐药性;超过80%的菌株对卡巴胺,皮佩拉西林/塔扎巴克坦,甘他和托布拉米具有耐药性.
- 与2016-2017年相比,在2020-2021年观察到产生两种或三种类型β-乳酸酶的菌株的显著增加 (94.2%对17.7%).
- 具有多个β-乳糖酶的分离体对tigecycline,tetracycline和doxycycline的耐药性更高 (p < 0.001).
结论:
- 从2016-2017年到2020-2021年,产生多个β-乳糖酶 (AmpC,KPC,ESBL) 的Acinetobacter baumannii的发生频率显著增加.
- 在晚期,人们注意到对安培西林/苏尔巴克坦,tigecycline,tetracycline和doxycycline的耐药性增加.
- 产生两种或三种β-lactamase类型与对四环素抗生素的耐药性增加密切相关.
相关概念视频
Development of Antibiotic Resistance
40
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
40
Antibiotic Selection
54.7K
Overview
54.7K
Antimicrobial Effectiveness
48
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
48
Gene Regulation in Microbial Communities: Quorum Sensing
39
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
39
Bacterial Cell Wall
58
The bacterial cell wall is an essential structural component that encases the plasma membrane, preserving cellular integrity, determining shape, and protecting against osmotic stress. This rigid yet flexible structure primarily comprises peptidoglycan, a polymer that forms a mesh-like matrix conferring mechanical strength and flexibility.Peptidoglycan Composition and StructurePeptidoglycan, the core of the bacterial cell wall, comprises alternating units of N-acetylglucosamine (NAG) and...
58


