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患有非晚期慢性病的患者的尿路马里诺布法宁:一个横截面研究
Davide Bolignano1,2, Marta Greco3,4, Mario D'Agostino1
1Nephrology and Dialysis Unit, Magna-Graecia University Hospital, 88100 Catanzaro, Italy.
Medicina (Kaunas, Lithuania)
|August 26, 2023
概括
慢性病 (CKD) 患者尿液中马里诺布法根因 (uMBG) 水平降低可能表明功能受损. 较低的UMBG与估计的淋巴细胞过率 (eGFR) 的降低有关,这表明它在CKD进展中发挥了作用.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 心血管内分泌学 心血管内分泌学
背景情况:
- 慢性病 (CKD) 的患病率在全球范围内不断增加,需要对早期疾病因素进行研究.
- 马里诺布发宁 (MBG) 是一种内源性心力动性类固醇,当度升高时,可能会加速损伤.
- 在非晚期CKD中研究尿路MBG (uMBG) 提供了对疾病机制的见解.
研究的目的:
- 探讨在非晚期慢性结核病患者中测量尿液水布法 (uMBG) 的临床意义.
- 评估CKD患者的UMBG水平和估计的淋巴球过率 (eGFR) 之间的关联.
- 在患有CKD的个体中确定UMBG水平的预测因子.
主要方法:
- 一项涉及108名成年CKD患者和25名健康对照者的横截面研究.
- 在临床,人体测量,实验室和仪器数据的同时,测量尿液中海洋布法素 (uMBG).
- 多变量回归模型用于分析关联并确定独立预测因素.
主要成果:
- 与健康对照组相比,CKD患者的UMBG水平显著降低 (0.37对0.64nmol/L,p=0.004).
- 在UMBG (p=0.03) 的三位体下降中观察到显著的EGFR下降趋势 (p=0.03).
- 在多变量分析 (β=0.248,p=0.01) 中,umBG 仍然与eGFR 强烈相关. uMBG的独立预测因素包括他类药物的使用 (β=-0.326,p=0.001),糖尿病 (β=0.243,p=0.009) 和尿中的 (β=0.204,p=0.01).
结论:
- 在CKD中减少的UMBG分泌可能意味着脏清除受损,可能会导致系统性MBG积累的有害影响.
- 需要进一步的研究来阐明在CKD中将UMBG,摄入量和糖尿病联系在一起的生物机制.
- 调查他类药物治疗是否减轻MBG在功能受损的不良影响,需要未来的研究.
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