从废棉制备的微晶纤维素的散装密度,流量特性和结晶性的修改
Sabiha Tasnim1, Md Fazlul Karim Tipu1, Md Sohel Rana1
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.
Materials (Basel, Switzerland)
|August 26, 2023
概括
研究人员从废弃棉花中修改了微晶纤维素 (MCC),以改善其用于药品片制剂的物理性能. 经过修改的MCC表现出增强的流动性和多样化的散装密度,为更广泛的药物兼容性提供了潜力.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 化学工程是化学工程的重要组成部分.
背景情况:
- 微晶纤维素 (MCC) 是一种广泛使用的制药辅助剂,主要作为直接可压缩片中的填充剂和粘合剂.
- 修改MCC的物理性质对于提高其与各种活性药物成分 (API) 和其他辅助剂的兼容性至关重要.
- 制药行业对开发成本效益高,可持续的MCC生产方法非常感兴趣.
研究的目的:
- 从废棉制备微晶纤维素 (MCC),使用改性化学工艺.
- 研究不同化学处理 (氧化度,温度,降水) 对MCC物理和结构性质的影响.
- 评估改性MCC作为药物配方中多功能辅助剂的潜力.
主要方法:
- 废棉被预先用合剂处理,然后进行纤维化,漂白和盐酸降解以产生MCC.
- 准备好的MCC经过进一步的修改,在不同的温度 (-20°C和室温) 上使用不同度的氧化,然后用盐酸或乙醇沉.
- 特性包括评估聚合度 (DP),FT-IR光谱,散密度,流量特性 (豪斯纳指数,卡尔指数,静止角),扫描电子显微镜 (SEM) 和X射线晶体学 (XRD).
主要成果:
- 准备的MCC的聚合度 (DP) 确定为216.
- 与未经修改的MCC (0.21) 相比,修改后的MCC在散装密度 (0.2530.594) 中显著增加,并显示出更好的流动性能.
- 在SEM分析中,在20°C下用氧化处理时,MCC颗粒从棒形变为圆形的形态转变,而XRD显示在修改的样本中,结晶度指数 (CrI) 从80.18%降至60.7%.
结论:
- 从废棉中获得的MCC的化学修饰成功改变了其物理特性,包括散装密度,流动性和形态学.
- 观察到的MCC特性变化归因于纤维素链重组的变化,受基度,温度和降水环境的影响.
- 这项研究表明,从可持续来源生产具有量身定制特征的MCC的可行性,可能扩大其在制药配方中的应用范围.
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