超声中介的眼部药物输送:从物理和仪器到未来的方向
Blair Duncan1, Raida Al-Kassas2, Guangming Zhang1
1School of Engineering, Faculty of Engineering & Technology, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, UK.
Micromachines
|August 26, 2023
概括
超声波通过克服解剖障碍来增强眼部药物输送. 本综述探讨了超声波物理,机制和用于改善眼部药物输送的应用,尽管对最佳参数缺乏共识.
科学领域:
- 眼科医生 眼科 眼科
- 生物医学工程 生物医学工程
- 药物输送系统 药物输送系统
背景情况:
- 眼部药物输送面临重大挑战,原因是眼部前后两部分存在解剖和生理障碍.
- 超声波已经成为克服这些障碍并改善药物透的有希望的方法.
- 目前的研究缺乏关于优化超声波系统配置和操作参数的共识,以有效的眼部药物输送.
研究的目的:
- 审查与药物输送相关的超声波的基本物理.
- 讨论超声波增强眼部药物输送的机制.
- 提供眼部药物输送路径,障碍和超声波介导眼部药物输送当前状态的概述.
主要方法:
- 关于超声物理及其在眼部药物输送中的应用的文献综述.
- 在超声波下对药物递送效率增加负责的现象的分析.
- 检查常见的眼部药物给药路径和障碍.
主要成果:
- 超声波生物效应可以有效地减轻眼壁,改善药物输送.
- 促进增强分娩的关键超声波现象包括化和热效应.
- 介绍了当前研究和超声中介眼部药物输送的未来方向的全面概述.
结论:
- 超声波具有显著的潜力,可以提高眼部药物输送效率.
- 需要进一步的研究来建立标准化的协议和超声波辅助眼部药物输送的最佳参数.
- 本综述综合了当前的知识,并强调了这种治疗方法的未来研究途径.
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