智能向配送系统,用于增强传统中医药中活性成分的抗瘤治疗
Chenglong Kang1, Jianwen Wang1, Ruotong Li1
1School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Molecules (Basel, Switzerland)
|August 26, 2023
概括
传统中国医学 (TCM) 提供强大的抗瘤化合物,但溶解性差限制了使用. 纳米系统增强TCM交付,提高溶解性,向性和生物可用性,以改善癌症治疗.
科学领域:
- 药理学 药理学是指药理学的学科.
- 纳米技术纳米技术
- 在瘤学瘤学.
背景情况:
- 传统中医 (TCM) 在瘤治疗方面有着悠久的历史,提供多目标和协同作用的抗瘤效应.
- 来自TCM的活性成分显示出希望,但面临着像溶解性差,高毒性和副作用等局限性.
- 纳米系统提供了一个有希望的方法来克服这些限制,在提供TCM癌症治疗.
研究的目的:
- 审查传统中医药中抗瘤活性成分的纳米输送系统.
- 分析物理封装和化学合纳米输送平台的优点和局限性.
- 讨论基于TCM的纳米系统的临床应用,毒性和未来的挑战.
主要方法:
- 对TCM抗瘤组件的纳米输送系统的文献综述.
- 基于药物加载方法的纳米输送系统的分类:物理封装和化学合.
- 对系统优势,局限性,临床应用和毒性的分析.
主要成果:
- 纳米输送系统显著提高了水溶性,准效率,体内稳定性和TCM组件的受控释放.
- 物理封装和化学合平台都为TCM交付提供了明显的优势和局限性.
- 与传统方法相比,纳米系统提高了药物输送效率和生物可用性.
结论:
- 纳米输送系统代表了利用TCM在癌症治疗中的重大进步.
- 进一步研究临床应用,毒性和开发对于实际实施至关重要.
- 优化纳米输送系统可以释放TCM在瘤学的全部治疗潜力.
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