从梅 (Maytenus dhofarensis) 中分离和识别植物化合物及其生物潜力
Fatma Al-Rubaiai1, Zakiya Zahran Al-Shariqi1, Khalsa S Al-Shabibi1
1Department of Chemistry, College of Science, Sultan Qaboos University, Al Khod, P.O. Box 36, Muscat 123, Oman.
Molecules (Basel, Switzerland)
|August 26, 2023
概括
新的化学化合物从阿曼灌木Maytenus dhofarensis中分离出来. 一种化合物lignanolactone (3) 通过抑制DPPH基来显示出抗氧化特性.
科学领域:
- 植物化学 植物化学
- 自然产品 化学 化学
- 药用植物研究 药用植物研究
背景情况:
- 梅 (Maytenus dhofarensis) 是阿曼的一个特有灌木.
- 众所周知,这种植物对放牧山羊造成不良影响.
- 它的化学成分尚未得到广泛研究.
研究的目的:
- 为了隔离和表征来自Maytenus dhofarensis的新化学化合物.
- 评估分离化合物的生物活性.
主要方法:
- 分析了M. dhofarensis果实和茎的和酸盐提取物.
- 使用IR,NMR和ESI-MS阐明了化合物结构.
- 通过使用DFT计算和NMR来确定相对配置.
- 通过酶抑制和DPPH激素清除试验来评估生物活性.
主要成果:
- 他们分离了三种新化合物:一种二-β-阿加洛类型的基二烯胺化物 (1),卢帕尼尔二酸盐 (2) 和一种林格诺拉克 (3).
- 化合物1对p38α和delta激酶没有抑制活性.
- 化合物3表现出显著的DPPH激素清除活性 (69.5%的抑制).
结论:
- 梅斯dhofarensis含有新的化学实体.
- 林格诺拉克 (3) 具有显著的抗氧化能力.
- 需要对M. dhofarensis的药用特性进行进一步的研究.
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