通过间接转移原子的C-H功能化的近期进展
Filip S Meger1, John A Murphy2
1Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, 16 Avinguda dels Països Catalans, 43007 Tarragona, Catalonia, Spain.
Molecules (Basel, Switzerland)
|August 26, 2023
概括
原子转移 (HAT) 能够实现C-H键的功能. 在光电还原催化和电化学的最新进展已经显著扩大了HATAT.
科学领域:
- 合成有机化学 合成有机化学
- 催化剂是一种催化剂.
- 开发方法的发展方法.
背景情况:
- 对合成化学而言,C-H键的功能化是至关重要的,它提供了新的回合成途径.
- 原子转移 (HAT) 是从C-H键产生基的关键机制.
- 传统的HAT反应包括巴顿酸盐和霍夫曼-洛夫勒-弗雷塔格反应.
研究的目的:
- 审查C-H,Si-H和Ge-H键功能的间接原子转移 (HAT) 的最新进展.
- 从2018-2023年开始批判性地讨论新的HAT试剂,机械洞察力,基质范围和上下文背景.
主要方法:
- 对2018年至2023年间出版的文献进行审查和批判性分析.
- 专注于间接的HAT方法,特别是使用光氧催化和电化学的方法.
- 讨论在HAT反应中实现位点选择性的策略.
主要成果:
- 光反氧催化和电化学已经成为HAT介导的C-H功能化的强大工具.
- 新的HAT试剂和协议的开发扩大了适用的基质的范围.
- 增强的机理性理解导致了改进的选址功能化策略.
结论:
- 间接的HAT,特别是通过光氧催化和电化学,代表了C-H功能化的显著演变.
- 对HAT试剂,机制和选择性的持续研究将进一步扩大其合成效用.
- 审查的方法为C-H,Si-H和Ge-H债券引入多种功能组提供了多功能方法.
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