对PCA形成的定量洞察 在内牙治疗中使用不同的赫西丁激活方法后,PCA形成的定量洞察
Barbara Czopik1, Aneta Woźniakiewicz2, Natalia Świętoniowska2
1Department of Conservative Dentistry with Endodontics, Faculty of Medicine, Institute of Stomatology, Jagiellonian University Medical College, Montelupich 4 St., 31-155 Kraków, Poland.
Molecules (Basel, Switzerland)
|August 26, 2023
概括
在使用超声波 (US) 和MDI方法激活2%的化 (CHX) 时,p-chloroaniline (PCA) 释放出来. 激活后的PCA水平与CHX自我降解相当,这表明牙周内使用的安全性.
科学领域:
- 牙周内科医院 牙周内科医院 牙周内科医院
- 牙科材料科学 牙科材料科学
- 分析化学 分析化学
背景情况:
- 赫西丁 (CHX) 是一种在内牙科中广泛使用的抗菌剂.
- 激活方法,如超声波 (美国) 和微-Mega设备 (MDI) 被用来提高CHX的功效.
- 对于CHX的潜在降解产物,如p-chloroaniline (PCA),及其安全影响存在担忧.
研究的目的:
- 在使用超声波 (美国) 和MDI方法激活2%的化 (CHX) 过程中对p-chloroaniline (PCA) 形成进行定量分析.
- 评估美国和MDI在类似根管的环境中激发CHX的安全性.
- 将激活过程中产生的PCA水平与存储的CHX.自降解过程中的PCA水平进行比较.
主要方法:
- 使用二极管阵列检测 (HPLC-DAD) 的高性能液态染色学对PCA进行定量分析.
- 激活2%的CHX与US (ISO 30和35K文件) 和MDI (ISO 30.06和35.06GP圆) 进行不同时间 (15-90秒).
- 在周围环境条件下,随着时间的推移 (0-21天) 评估货架存储的2%CHX中的PCA.
主要成果:
- 在所有样本中检测到PCA,无论激活方法或持续时间如何.
- 随着美国的激活,PCA度显示出与时间相关的增加 (p < 0.05).
- 类似的趋势,虽然在统计学上不显著,但在MDI激活 (p > 0.05) 时观察到.
- 在储存的2%CHX中也检测到PCA,其度与储存时间相关.
- 来自CHX激活的PCA平均度并不显著高于自降解的PCA度.
结论:
- 使用US和MDI方法激活2%的CHX会导致PCA释放.
- 在激活过程中释放的PCA度与储存2%的CHX.自降解的PCA度相当.
- 这些发现表明,在内治疗中,US和MDI激活CHX对于PCA形成是安全的.
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