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从牙科患者中分离出来的致细菌的表型分析,分子表征和抗生素图

Khushbu Farva¹, Huma Sattar¹, Hayat Ullah²

¹Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore 54000, Pakistan.

|August 26, 2023

概括

牙损是一种常见的疾病,但生和阿姆拉提取物显示出强烈的抗菌活性. 这些天然化合物可以作为治疗牙科问题的合成抗生素的有效替代品.

科学领域:

微生物学微生物学
生物化学生物化学
药理学药理学是指药理学的学科.

背景情况:

牙损是一种流行的生物膜介导疾病,影响牙硬组织.
尽管取得了进展,但牙仍然是全球重要的健康问题.
了解病原体的流行率和有效的治疗方法至关重要.

研究的目的:

优化 cariogenic 病原体的微生物和分子检测.
根据各种因素来确定空性细菌的流行率.
评估草本提取物和合成抗生素的体外抗菌活性.

主要方法:

收集了900名患者的口腔样本,用于生物化学和分子查.
测试了植物提取物的抗菌活性 (生,大,尼姆,图尔西,阿姆拉,).
评估过的合成抗生素 (青素,阿莫西西林,西普罗夫洛克萨等) 针对孤立的菌株.

主要成果:

确定了 *Staphylococcus mutans* (29.11%) 和 *Streptococcus sobrinus* (28.11%) 作为主导菌株.
生和阿姆拉提取物显示出显著的抑制区域 (分别为22.36毫米和20.01毫米).
齐普罗夫洛克萨和莱沃弗洛克萨是对测试微生物最有效的合成抗生素.

结论:

生和阿姆拉植物提取物显示出对牙科疾病的合成抗生素有效替代品的潜力.
优化的检测技术提高了对化病原体流行率的理解.
这项研究强调了天然化合物的治疗潜力,用于治疗牙.

关键词:

抗微生物活性的抗微生物活性.生物膜是一种生物膜.牙腐烂是指牙的腐烂.这是一种民族医学药物.植物提取物植物提取物合成的抗微生物药物.

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