肠道微生物和相关代谢物标记物用于结肠直肠癌诊断
Areej A Alhhazmi1, Renad M Alhamawi1, Reema M Almisned2
1Medical Laboratories Technology Department, College of Applied Medical Sciences, Taibah University, P.O. Box 344, Al-Madinah Al-Munawarah 42353, Saudi Arabia.
Microorganisms
|August 26, 2023
概括
像Fusobacterium和Porphyromonas这样的肠道微生物与结直肠癌 (CRC) 和晚期腺瘤有着密切的联系. 这些微生物标记物可以帮助诊断CRC和晚期腺瘤,但代谢物标记物需要进一步研究.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
背景情况:
- 结肠直肠癌 (CRC) 是全球癌症死亡的主要原因.
- 肠道微生物失调症及其代谢物与结直肠腺瘤 (ADA) 和CRC发展有关.
- 了解这些关联对于早期发现和预防策略至关重要.
研究的目的:
- 系统地审查肠道微生物标记物和/或代谢物与ADA和CRC之间的临床关联.
- 为了确定可靠的微生物和代谢物生物标志物来诊断ADA和CRC.
- 评估这些生物标志物的证据质量.
主要方法:
- 对比ADA/CRC与健康对照 (HC) 的受控试验的系统审查.
- 包括使用16s rRNA,全基因组测序或实时PCR进行微生物组分析的研究.
- 包括使用从肠道或血清/血样本中非向性或向性代谢物分析的研究.
- 使用Cochrane干预措施系统审查手册进行质量评估.
主要成果:
- 强有力的证据确定了Fusobacterium和Porphyromonas作为微生物标记物,将ADA与CRC区分开来.
- 九种微生物标记物,包括Lachnospiraceae-Lachnoclostridium和Enterobacteriaceae,与CRC与HC有关.
- 对代谢物标记物的证据通常质量不足以进行可靠的发现.
结论:
- 已识别的肠道微生物标记物显示出在ADA和CRC的诊断面板中使用的潜力.
- 需要进一步的研究来验证代谢物标记物在结直肠癌中的诊断或预后应用.
- 微生物组分析为改善结直肠癌检测提供了一个有希望的途径.
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