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关联肠道微生物群和循环激素与损伤计数和皮肤生物物理特征

Raja K Sivamani^1,2,3,4, Jessica Maloh¹, Yvonne Nong¹

¹Integrative Skin Science and Research, Sacramento, CA 95815, USA.

|August 26, 2023

概括

这项研究发现,压力,荷尔蒙和肠道细菌会影响病变数量. 像Clostridium这样的特定细菌与炎症性相关,而Actinomyces与非炎症性相关.

科学领域:

皮肤病学和微生物学研究侧重于的多因素性质.

背景情况:

是一种常见的炎症性皮肤疾病,受内在和外在因素的影响.
之前的研究探讨了与激素,压力或微生物组之间的联系.
在将这些因素与特定的病变数量相关联方面存在差距,将炎症与非炎症类型区分开来.

研究的目的:

调查激素水平,压力指标,肠道微生物组合和病变计数之间的相关性.
为了区分炎症与非炎症病变的相关性.
探索肠道 - 精神 - 压力 - 皮肤轴在病原性.

主要方法:

招募20名患有轻度至中度的参与者.
收集荷尔蒙水平和肠道微生物群样本.
对收集的数据与炎症和非炎症面部病变数的相关性分析.
评估使用正常化的峰值与低谷比率来评估压力.

主要成果:

非炎症性病变与脂质分泌率的相关性很弱,与皮肤水分的反相关性.
压力水平与皮肤水分相关,与皮脂分泌相反.
皮脂分泌与丸激素相关;面部水分与雌激素相关.
肠道微生物组分析显示了差异性相关性: *Clostridium sp AF 23-8*具有炎症性病变, *Actinomyces naeslundii str Howell 279*具有非炎症性病变.

结论:

循环的荷尔蒙和压力水平与皮肤的生物物理性质和病变的严重程度有关.
不同的肠道细菌与炎症性或非炎症性病变类型相关.
这些发现支持进一步研究的复杂肠-心-压力-皮肤轴.

关键词:

一般性 (acne vulgaris) 是一种生物物理特征生物物理特征在这里,我们可以看到子子.激素激素激素激素激素微生物组是一个微生物组.皮肤皮肤皮肤

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