婴儿唾液微生物群活动调节对神经发育的营养影响
Terrah Keck-Kester1, Steven D Hicks1
1Department of Pediatrics, Penn State College of Medicine, Hershey, PA 17033, USA.
Microorganisms
|August 26, 2023
概括
微生物活动影响婴儿的神经发育,鱼类消费的好处可能是由肠道微生物调解的. 需要进一步的研究,以在更大的试验中证实这些发现.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 儿科 儿科 儿科
- 环境健康 环境健康
背景情况:
- 神经发育是一个复杂的过程,受到环境因素的影响,包括营养,健康的社会决定因素 (SDOH) 和微生物群.
- 了解这些因素如何相互作用,对于确定支持健康婴儿发育的干预措施至关重要.
研究的目的:
- 测试微生物活动调节营养对婴儿神经发育的影响的假设.
- 确定与神经发育迟缓 (NDD) 相关的特定微生物和营养因素.
主要方法:
- 这是一项对142名婴儿进行的纵向队列研究.
- 6个月后通过RNA测序测量唾液微生物组活性.
- 婴儿营养被纵向评估;神经发育延迟 (NDD) 在18个月时使用幼儿福祉调查确定.
主要成果:
- 逻辑回归模型解释了神经发育小组中33.3%的差异.
- NDD与西班牙裔族裔有关,没有鱼类消费,并且增加了*Candidatus Gracilibacteria*活动.
- 保护因素包括1977年以后建造的房屋和增加的*Chlorobi*活动. 微生物的α多样性调节了鱼类消费对NDD的影响.
结论:
- 鱼类消费对神经发育的好处可能是由微生物多样性介导的.
- 特定的微生物和营养因素,与SDOH一起,在婴儿神经发育中发挥作用.
- 需要在更大的随机试验中进一步确认.
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